Anti-MAF Antibody Prodrug, Protease Activated (VS-1025-YC90)
CAT#: VS-1025-YC90
The Anti-MAF Antibody Prodrug, Protease Activated (VS-1025-YC90) is an antibody prodrug comprised of a recombinant rabbit antibody targeting human MAF, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to MAF protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to MAF effectively. MAF (V-maf musculoaponeurotic fibrosarcoma oncogene homolog) is a transcription factor that is frequently overexpressed in cancers, most notably multiple myeloma, often due to chromosomal translocation. As a potent oncogene, high MAF levels drive the expression of genes that promote malignant proliferation and bone destruction.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human duodenum
Immunohistochemical staining of human duodenum shows moderate nuclear and cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28289/59696_A_9_2_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Glial cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10296/32682_B_9_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: nuclear Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10296/32682_A_8_3.jpg
Normal Tissue
Figure 4 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Hepatocytes Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10296/32682_A_8_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10296/32682_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10296/32682_A_5_6.jpg
Normal Tissue
Figure 7 Lymph node
Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10296/32682_A_9_8.jpg
RNA Expression
Figure 8 RNA cell line category: Group enriched (Karpas-707, RPMI-8226)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000178573-MAF
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Specifications
- Host Animal
- Rabbit
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human MAF
- Target
- MAF
- Species Reactivity
- Human
- Isotype
- IgG
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene.
- Alternative Names
- MAF BZIP Transcription Factor; V-Maf Avian Musculoaponeurotic Fibrosarcoma Oncogene Homolog; Proto-Oncogene C-Maf; Avian Musculoaponeurotic Fibrosarcoma (MAF) Protooncogene; V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog; T Lymphocyte C-Maf Long Form; Transcription Factor Maf;
- Gene ID
- 4094
- UniProt ID
- O75444
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "MAF"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-4079z | Mouse Anti-MAF Recombinant Antibody (clone 35G11) | WB, IP, IF, ELISA | Mouse IgG1, κ |
| MOB-0267CT | Recombinant Mouse anti-Human MAF Monoclonal antibody (EML558) | WB | |
| HPAB-693-FY | Rabbit Anti-MAF Recombinant Antibody (HPAB-693-FY) | WB, SPR | Rabbit IgG |
| VS3-XY3423 | Rabbit Anti-MAF Recombinant Antibody (clone R04-6K7) | IHC-P | Rabbit IgG |
| VS13-YC681 | Rabbit Anti-MAF Recombinant Antibody (VS13-YC681) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B020(A) | Recombinant Anti-human Maf Intrabody [(D-Arg)9] | IF, ELISA, FuncS | scFv-(D-Arg)9 |
| IAB-B020(G) | Recombinant Anti-human Maf Intrabody [+36 GFP] | FC, IF, FuncS | scFv-(+36GFP) |
| IAB-B020(T) | Recombinant Anti-human Maf Intrabody [Tat] | CO-IP, FuncS | scFv-Tat |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2120 | Hi-Affi™ Recombinant Rabbit Anti-MAF Monoclonal Antibody (DS2120AB) | WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-693-FY-S(P) | Rabbit Anti-MAF Recombinant Antibody; scFv Fragment (HPAB-693-FY-S(P)) | WB, ELISA | Rabbit scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-693-FY-F(E) | Rabbit Anti-MAF Recombinant Antibody; Fab Fragment (HPAB-693-FY-F(E)) | WB, ELISA | Rabbit Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4164 | Anti-MAF Immunohistochemistry Kit | IHC |
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