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MAF

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For Research Use Only. Not For Clinical Use.


Background

maf, or Septum formation protein Maf, is a protein involved in bacterial cell division, particularly in controlling the proper placement and formation of the septum. Maf ensures that cell division occurs accurately at the mid-cell, preventing anucleate cells and maintaining genetic integrity during proliferation.
Protein class

Cancer-related genes, Disease related genes, Human disease related genes, Transcription factors

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Hepatic stellate cells, Kupffer cells, Inhibitory neurons, Proximal enterocytes, Hofbauer cells)

Immune cell specificity

Immune cell enriched (basophil)

Cell line specificity

Group enriched (Karpas-707, RPMI-8226)

Interaction

Homodimer or heterodimer with other bHLH-Zip transcription factors. Binds DNA as a homodimer or as a heterodimer. Heterotetramer of two MAF and two USF2. Interacts with PAX6; the interaction is direct. Interacts with MYB; interaction takes place weakly in normal T-cells and increases in T-cells following stimulation through the TCR engagement. Interacts with MYB; the ternary complex formed with MYB and the CD13 promoter is regulated in response to differentiating signals. Interacts with USF2; the interaction inhibits its DNA-binding activity on the L7 promoter. Interacts with CREBBP, EP300 and ETS1 (By similarity).

Molecular function

Activator, DNA-binding, Repressor

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