Rabbit Anti-MAPK6 Recombinant Antibody (clone R04-5B8) (CAT#: VS3-FY1761)
Clone R04-5B8 is a rabbit recombinant monoclonal antibody that confidently identify human MAPK6. It cross-reacts with mouse. The antibody is recommended for detection of MAPK6 protein by WB, IHC-P, IP. This MAPK6 antibody was used in western blot analysis of MAPK6 in 3T3, Hela lysates.
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WB
Figure 1 Anti-MAPK6 Antibody (VS3-FY1761) in WB.
The MAPK6 expression in 3T3, Hela lysates were detected using the anti-MAPK6 by western blot assay.
Specifications
- Immunogen
- Synthetic peptides of human MAPK6
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Mouse MAPK6
- Species Reactivity
- Human, Mouse
- Clone
- R04-5B8
- Applications
- Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation
- MW
- The calculated weight of the target protein is approximately 83 kDa, while the observed molecular weight stands at 105 kDa.
- Related Disease
- Pulmonary Immaturity and Chronic Myelogenous Leukemia, Bcr-Abl1 Positive
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/50-1/100
Immunoprecipitation: 1/20
Target
- Alternative Names
- Mitogen-Activated Protein Kinase 6; Extracellular Signal-Regulated Kinase 3; MAP Kinase Isoform P97; MAP Kinase 6; EC 2.7.11.24; P97-MAPK; MAPK 6; PRKM6; ERK-3
- Gene ID
- 5597
- UniProt ID
- Q16659
- Sequence Similarities
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Phosphorylated at Ser-189 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites.1 Publication
Ubiquitination at Met-1 leads to degradation by the proteasome pathway.
- Protein Refseq
- XP_005254594.1; XP_005254595.1; XP_011520084.1; XP_047288803.1; XP_047288804.1
- Function
- Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "MAPK6"
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IgG Antibodies
Chicken IgY Antibodies
Rabbit Monoclonal Antibodies
IHC Kits & Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1201CT | Recombinant Mouse anti-Human MAPK6 Monoclonal antibody (6F2) | ICC, IF, WB | |
| VS3-QX743 | Mouse Anti-MAPK6 Recombinant Antibody (clone 4E8) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| VS7-0425-WR357 | Mouse Anti-MAPK6 Monoclonal Antibody (VS7-0425-WR357) | WB, FC, ELISA | Mouse IgG |
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