Rabbit Anti-MAPK6 Recombinant Antibody (clone R04-5B8) (CAT#: VS3-FY1761)
Clone R04-5B8 is a rabbit recombinant monoclonal antibody that confidently identify human MAPK6. It cross-reacts with mouse. The antibody is recommended for detection of MAPK6 protein by WB, IHC-P, IP. This MAPK6 antibody was used in western blot analysis of MAPK6 in 3T3, Hela lysates.
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WB
Figure 1 Anti-MAPK6 Antibody (VS3-FY1761) in WB.
The MAPK6 expression in 3T3, Hela lysates were detected using the anti-MAPK6 by western blot assay.
Specifications
- Immunogen
- Synthetic peptides of human MAPK6
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Mouse MAPK6
- Species Reactivity
- Human, Mouse
- Clone
- R04-5B8
- Applications
- Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation
- MW
- The calculated weight of the target protein is approximately 83 kDa, while the observed molecular weight stands at 105 kDa.
- Related Disease
- Pulmonary Immaturity and Chronic Myelogenous Leukemia, Bcr-Abl1 Positive
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/50-1/100
Immunoprecipitation: 1/20
Target
- Alternative Names
- Mitogen-Activated Protein Kinase 6; Extracellular Signal-Regulated Kinase 3; MAP Kinase Isoform P97; MAP Kinase 6; EC 2.7.11.24; P97-MAPK; MAPK 6; PRKM6; ERK-3
- Gene ID
- 5597
- UniProt ID
- Q16659
- Sequence Similarities
- Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Phosphorylated at Ser-189 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites.1 Publication
Ubiquitination at Met-1 leads to degradation by the proteasome pathway.
- Protein Refseq
- XP_005254594.1; XP_005254595.1; XP_011520084.1; XP_047288803.1; XP_047288804.1
- Function
- Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "MAPK6"
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IgG Antibody Products
Chicken IgY Antibody Products
Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1201CT | Recombinant Mouse anti-Human MAPK6 Monoclonal antibody (6F2) | ICC/IF, WB | |
| VS3-QX743 | Mouse Anti-MAPK6 Recombinant Antibody (clone 4E8) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| VS7-0425-WR357 | Mouse Anti-MAPK6 Monoclonal Antibody (VS7-0425-WR357) | WB, FC, ELISA | Mouse IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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