AibGenesis™ Rabbit Anti-MCM4 Recombinant Antibody (AibG-Rb-MC568)
CAT#: VS-0426-FY568
Established through our AI-powered antibody discovery platform, this Rabbit IgG targets MCM4. Validated for WB, FC, and IP in Human and Mouse, it provides exceptional sensitivity for researchers investigating the helicase activity of the MCM complex and its critical role in eukaryotic DNA replication.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4873/if_selected.jpg
Normal Tissue
Figure 2 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4497/16414_A_9_5.jpg
Normal Tissue
Figure 3 Testis
Leydig cells Staining: Low Intensity: Moderate Quantity: <25% Pachytene spermatocytes Staining: High Intensity: Strong Quantity: 75%-25% Preleptotene spermatocytes Staining: Medium Intensity: Strong Quantity: <25% Round or early spermatids Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: Medium Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4497/16414_A_6_6.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4497/16414_A_8_8.jpg
Normal Tissue
Figure 5 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Nuclear Glial cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4497/16414_B_7_5.jpg
Normal Tissue
Figure 6 Colon
Endocrine cells Staining: Medium Intensity: Moderate Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Enterocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Enterocytes - Gradient Gradient: Descending Enterocytes - Fibroblasts Staining: Medium Intensity: Moderate Mucosal lymphoid cells Staining: Medium Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4497/16414_A_8_3.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000104738-MCM4
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Specifications
- Immunogen
- Human
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human MCM4
- Species Reactivity
- Human, Mouse
- Clone
- AibG-Rb-MC568
- Applications
- Western Blot, Flow Cytometry, Immunoprecipitation
- Conjugate
- Unconjugated, Biotin and FITC are available.
- Related Disease
- Natural Killer Cell and Glucocorticoid Deficiency
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity purified
- Format
- Liquid
- Buffer
- PBS, 0.05% Protective protein, 50% Glycerol
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Applications
- Application Notes
- Western Blot (1:1000-1:2000), Flow Cytometry (1:20-1:100), Immunoprecipitation (1:20-1:50)
Target
- Alternative Names
- CDC21; CDC54; hCdc21; P1-CDC21; MCM4
- UniProt ID
- P33991
- Long Name
- Minichromosome Maintenance Complex Component 4
- Sequence Similarities
- Belongs to the MCM family.
- Cellular Localization
- Chromosome, Nucleus
- Post Translation Modifications
- Sumoylated; SUMO2 modified in response to stress caused by inhibition of proteasome activity (in vitro). (P33991-MCM4_HUMAN)
Ubiquitination at Lys123, Lys163, Lys179, Lys216, Lys220, Lys349, Lys381, Lys439, Lys444, Lys450, Lys536, Lys600, Lys628, Lys752, Lys762, Lys770, Lys814, Lys819, and Lys858 (NX_P33991 [NX_P33991-1])
Modification sites at PhosphoSitePlus (P33991)
Glycosylation from GlyGen (P33991) 2 sites, 1 O-linked glycan (2 sites)
- Protein Refseq
- NP_005905.2; NP_877423.1
- Function
- Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "MCM4"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2192 | Hi-Affi™ Recombinant Rabbit Anti-MCM4 Monoclonal Antibody (DS2192AB) | WB, IP, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC4354 | PE-A*69:01/Human MCM4 (AHSTIMPRL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-FY2030 | Rabbit Anti-MCM4 Recombinant Antibody (clone R02-8F8) | WB, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1321 | Anti-MCM4 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4309 | Anti-Human MCM4 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS14-YC449 | AibGenesis™ Rabbit Anti-MCM4 Recombinant Antibody (AibG-Rb-CM4248) | WB | Rabbit IgG |
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