Rabbit Anti-MMP2 Recombinant Antibody (VS13-YC734)
CAT#: VS13-YC734
The Rabbit Anti-MMP2 Recombinant Antibody is specific for human and mouse MMP2. MMP2 encodes a gelatinase enzyme cleaving extracellular components, activated by glutathiolation without proteolysis, tied to processes like metastasis and certain syndromes, with multiple spliced variants. The anti-MMP2 antibody can be used for Western blot (1/1000-1/2000), Immunohistochemistry-paraffin (1/50-1/200).
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1939/if_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human stomach
Immunohistochemical staining of human stomach shows moderate cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1939/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human endometrium
Immunohistochemical staining of human endometrium shows moderate cytoplasmic positivity in stromal cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2788/6952_B_5_3_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2788/6952_B_9_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2788/6952_A_9_3.jpg
Normal Tissue
Figure 6 Liver
Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1939/7518_A_9_4.jpg
Normal Tissue
Figure 7 Gallbladder
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1939/7518_A_4_4.jpg
Normal Tissue
Figure 8 Kidney
Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2788/6952_A_8_5.jpg
Normal Tissue
Figure 9 Testis
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2788/6952_A_6_6.jpg
Normal Tissue
Figure 10 Lymph node
Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1939/7518_A_8_8.jpg
RNA Expression
Figure 11 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, hTERT-RPE1, U-87 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000087245-MMP2
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Specifications
- Immunogen
- Recombinant human MMP2, aa 101-150.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Mouse MMP2
- Species Reactivity
- Human, Mouse
- Applications
- WB, IHC-P
- Conjugate
- NONE
- Related Disease
- Cardiovascular Disease
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/1000-1/2000
Immunohistochemistry-paraffin (IHC-P): 1/50-1/200
Target
- Alternative Names
- Matrix Metallopeptidase 2; Matrix Metalloproteinase-2; EC 3.4.24.24; CLG4A; MMP-2; TBE-1; Matrix Metalloproteinase 2 (Gelatinase A, 72kDa Gelatinase, 72kDa Type IV Collagenase); Matrix Metallopeptidase 2 (Gelatinase A, 72kDa Gelatinase, 72kDa Type IV Collagenase); Matrix Metalloproteinase-II; 72 KDa Type IV Collagenase;
- Gene ID
- 4313
- UniProt ID
- P08253
- Long Name
- Matrix Metallopeptidase 2
- Sequence Similarities
- Belongs to the peptidase M10A family.
- Cellular Localization
- Secreted; Nucleus; Cytoplasm; Cell membrane; Mitochondrion; Extracellular matrix
- Protein Refseq
- NP_001121363.1; NP_001289437.1; NP_001289438.1
- Function
- Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.
PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels.
Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-666-F(E) | Recombinant Anti-human MMP2 Antibody Fab Fragment | FC, Neut, Funcs | Fab |
| MHH-666-F(E) | Recombinant Human Anti-human MMP2 Antibody Fab Fragment | WB, FC, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-666-S(P) | Recombinant Anti-human MMP2 Antibody scFv Fragment | FC, WB, FuncS | scFv |
| MHH-666-S(P) | Recombinant Human Anti-human MMP2 Antibody scFv Fragment | IF, Neut, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0566CL | Mouse Anti-MMP2 Recombinant Antibody (TAB-0566CL) | Inhib | Mouse IgG |
| TAB-0566CL-S(P) | Mouse Anti-MMP2 Recombinant Antibody; scFv Fragment (TAB-0566CL-S(P)) | Inhib | Mouse scFv |
| TAB-0566CL-F(E) | Mouse Anti-MMP2 Recombinant Antibody; Fab Fragment (TAB-0566CL-F(E)) | Inhib | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0365MZ | Chicken Anti-MMP2 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1747CQ | Recombinant Mouse Anti-MMP2 Antibody (CA719E3C) | Inhib, IHC, WB, ICC | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2253 | Hi-Affi™ Recombinant Rabbit Anti-MMP2 Monoclonal Antibody (DS2253AB) | WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-2037-CN | Rabbit Anti-MMP2 Polyclonal Antibody (MRO-2037-CN) | WB, IF, IHC, FC | Rabbit IgG |
| ZG-0286C | Mouse Anti-MMP2 Recombinant Antibody (ZG-0286C) | WB | Mouse IgG |
| ZG-0729F | Mouse Anti-MMP2 Recombinant Antibody (clone 4D3) | ELISA, WB, IHC | Mouse IgG1 |
| VS3-WK1662 | Recombinant Mouse Anti-MMP2 Capture Antibody (clone 12C10) | ELISA | Mouse IgG1 |
| VS3-WK1663 | Recombinant Mouse Anti-MMP2 Detection Antibody (clone 12A4) | ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY325 | Mouse Anti-NHP MMP2 Recombinant Antibody (clone 101) | WB, IHC, ICC, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1355 | Anti-MMP2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4452 | Anti-Mouse MMP2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4451 | Anti-Human MMP2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC226 | Recombinant Anti-MMP2 Eliminating Antibody, pH-Sensitive (3G11 var.) | Antigen-Sweeping In Vivo. | Human IgG1 |
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