Mouse Anti-MR1 Recombinant Antibody (VS3-FY2807) (CAT#: VS3-FY2807)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• Human MR1

• Species Reactivity
• Human

• Applications
• Immunohistochemistry, Immunocytochemistry, Flow cytometry, ELISA

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 39.4 kDa.

• Related Disease
• Immune Deficiency Disease and Hemochromatosis, Type 1

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Immunohistochemistry: 1/50-1/200
  Immunocytochemistry: 1/50-1/200
  Flow cytometry: 1/50-1/200
  ELISA: 1/1000-1/10000

• Alternative Names
• Major Histocompatibility Complex, Class I-Related; Major Histocompatibility Complex, Class I-Like Sequence; Major Histocompatibility Complex Class I-Related Gene Protein; Class I Histocompatibility Antigen-Like Protein; MHC Class-I Related-Gene Protein; MHC Class I-Related Gene Protein; MHC Class I-Like Antigen MR-1; HLALS

• Gene ID
• 3140

• UniProt ID
• Q95460

• Sequence Similarities
• Belongs to the MHC class I family.

• Cellular Localization
• Cell membrane
  Single-pass type I membrane protein

• Post Translation Modifications
• N-glycosylated. (Q95460-HMR1_HUMAN)
  Glycosylation at Asn107 (NX_Q95460 [NX_Q95460-1])
  Ubiquitination at Lys195 (NX_Q95460 [NX_Q95460-1])
  Modification sites at PhosphoSitePlus (Q95460)
  Glycosylation from GlyGen (Q95460) 1 site

• Protein Refseq
• XP_047274855.1; XP_054192199.1; XP_054192200.1; NP_001181928.1

• Function
• Acts as an immune sensor of cancer cell metabolome (PubMed:31959982).
  May present a tumor-specific or -associated metabolite essential for cancer cell survival to a pan-cancer TCR consisting of TRAV38.2-DV8*TRAJ31 alpha chain paired with a TRBV25.1*TRBJ2.3 beta chain on a non-MAIT CD8-positive T cell clone (MC.7.G5), triggering T cell-mediated killing of a wide range of cancer cell types.

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

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