Rabbit Anti-MTAP Recombinant Antibody (VS3-FY2810) (CAT#: VS3-FY2810)
The anti-MTAP antibody is a rabbit recombinant monoclonal antibody that with high affinity for human MTAP protein. It cross-reacts with mouse, rat species. This monoclonal antibody proves valuable in disease research related to Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma and Diaphyseal Medullary Stenosis-Bone Malignancy Syndrome. This monoclonal antibody is suitable for employment in Immunoprecipitation (1/20), Western Blot (1/500-1/1000).
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HeLa
(Immunofluorescent staining of human cell line HeLa shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/46915/1916_C10_25_cr5c99f3ba8408a_selected.jpg
(Immunofluorescent staining of human cell line HeLa shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/46915/1916_C10_25_cr5c99f3ba8408a_selected.jpg
Figure 2 IHC staining of human endometrium
(Immunohistochemical staining of human endometrium shows moderate nuclear and cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/80036/170588_B_5_3_selected.jpg
(Immunohistochemical staining of human endometrium shows moderate nuclear and cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/80036/170588_B_5_3_selected.jpg
Figure 3 IHC staining of human esophagus
(Immunohistochemical staining of human esophagus shows strong nuclear and cytoplasmic positivity in squamous epithelial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/80037/170596_B_6_1_selected.jpg
(Immunohistochemical staining of human esophagus shows strong nuclear and cytoplasmic positivity in squamous epithelial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/80037/170596_B_6_1_selected.jpg
Figure 4 Cerebral cortex
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/80037/170596_B_7_5.jpg
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/80037/170596_B_7_5.jpg
Figure 5 Colon
(Glandular cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/80037/170596_A_9_3.jpg
(Glandular cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/80037/170596_A_9_3.jpg
Figure 6 Kidney
(Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/80037/170596_A_9_5.jpg
(Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/80037/170596_A_9_5.jpg
Figure 7 Lymph node
(Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/80037/170596_A_7_8.jpg
(Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/80037/170596_A_7_8.jpg
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000099810-MTAP
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000099810-MTAP
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat MTAP
- Species Reactivity
- Human, Mouse, Rat
- Applications
- Western Blot, Immunoprecipitation
- Conjugate
- Unconjugated, FITC
- Related Disease
- Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma and Diaphyseal Medullary Stenosis-Bone Malignancy Syndrome
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunoprecipitation: 1/20
Western Blot: 1/500-1/1000
Target
- Alternative Names
- Methylthioadenosine Phosphorylase; S-Methyl-5-Thioadenosine Phosphorylase; 5-Methylthioadenosine Phosphorylase; MTA Phosphorylase; MTAPase; MSAP; Epididymis Luminal Protein 249; MeSAdo Phosphorylase
- Gene ID
- 4507
- UniProt ID
- Q13126
- Sequence Similarities
- Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Ubiquitination at Lys40 and Lys71 (NX_Q13126 [NX_Q13126-1])
Modification sites at PhosphoSitePlus (Q13126)
Glycosylation from GlyGen (Q13126) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001382969.1; NP_001382970.1; NP_001382971.1; NP_001382972.1; NP_001382973.1
- Function
- Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
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Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0930MZ | Recombinant Mouse Anti-Human MTAP Antibody | ICC/IF | Mouse antibody |
| VS3-FY966 | Recombinant Rabbit Anti-MTAP Antibody (VS3-FY966) | IA | Rabbit IgG |
| VS3-FY2040 | Rabbit Anti-MTAP Recombinant Antibody (clone R07-5A0) | WB | Rabbit IgG |
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