Rabbit Anti-MTAP Recombinant Antibody (VS3-FY2810) (CAT#: VS3-FY2810)
The anti-MTAP antibody is a rabbit recombinant monoclonal antibody that with high affinity for human MTAP protein. It cross-reacts with mouse, rat species. This monoclonal antibody proves valuable in disease research related to Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma and Diaphyseal Medullary Stenosis-Bone Malignancy Syndrome. This monoclonal antibody is suitable for employment in Immunoprecipitation (1/20), Western Blot (1/500-1/1000).
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HeLa
(Immunofluorescent staining of human cell line HeLa shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/46915/1916_C10_25_cr5c99f3ba8408a_selected.jpg
(Immunofluorescent staining of human cell line HeLa shows localization to nucleoplasm & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/46915/1916_C10_25_cr5c99f3ba8408a_selected.jpg
Figure 2 IHC staining of human endometrium
(Immunohistochemical staining of human endometrium shows moderate nuclear and cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/80036/170588_B_5_3_selected.jpg
(Immunohistochemical staining of human endometrium shows moderate nuclear and cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/80036/170588_B_5_3_selected.jpg
Figure 3 IHC staining of human esophagus
(Immunohistochemical staining of human esophagus shows strong nuclear and cytoplasmic positivity in squamous epithelial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/80037/170596_B_6_1_selected.jpg
(Immunohistochemical staining of human esophagus shows strong nuclear and cytoplasmic positivity in squamous epithelial cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/80037/170596_B_6_1_selected.jpg
Figure 4 Cerebral cortex
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/80037/170596_B_7_5.jpg
(Endothelial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/80037/170596_B_7_5.jpg
Figure 5 Colon
(Glandular cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/80037/170596_A_9_3.jpg
(Glandular cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/80037/170596_A_9_3.jpg
Figure 6 Kidney
(Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/80037/170596_A_9_5.jpg
(Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/80037/170596_A_9_5.jpg
Figure 7 Lymph node
(Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/80037/170596_A_7_8.jpg
(Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/80037/170596_A_7_8.jpg
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000099810-MTAP
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000099810-MTAP
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat MTAP
- Species Reactivity
- Human, Mouse, Rat
- Applications
- Western Blot, Immunoprecipitation
- Conjugate
- Unconjugated, FITC
- Related Disease
- Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma and Diaphyseal Medullary Stenosis-Bone Malignancy Syndrome
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunoprecipitation: 1/20
Western Blot: 1/500-1/1000
Target
- Alternative Names
- Methylthioadenosine Phosphorylase; S-Methyl-5-Thioadenosine Phosphorylase; 5-Methylthioadenosine Phosphorylase; MTA Phosphorylase; MTAPase; MSAP; Epididymis Luminal Protein 249; MeSAdo Phosphorylase
- Gene ID
- 4507
- UniProt ID
- Q13126
- Sequence Similarities
- Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Ubiquitination at Lys40 and Lys71 (NX_Q13126 [NX_Q13126-1])
Modification sites at PhosphoSitePlus (Q13126)
Glycosylation from GlyGen (Q13126) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001382969.1; NP_001382970.1; NP_001382971.1; NP_001382972.1; NP_001382973.1
- Function
- Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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IgG Antibody Products
MHC Tetramer Products for Cancer
Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0930MZ | Recombinant Mouse Anti-Human MTAP Antibody | ICC/IF | Mouse antibody |
| VS3-FY966 | Recombinant Rabbit Anti-MTAP Antibody (VS3-FY966) | IA | Rabbit IgG |
| VS3-FY2040 | Rabbit Anti-MTAP Recombinant Antibody (clone R07-5A0) | WB | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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