Recombinant Anti-MUC5AC Eliminating Antibody, pH-Sensitive (VS-0625-YC232)
CAT#: VS-0625-YC232
The anti-MUC5AC eliminating antibody is an engineered pH-sensitive antibody against human MUC5AC. MUC5AC, a high molecular weight mucin, is re-expressed in the colon during carcinogenesis. The antibody has a novel MUC5AC-sweeping activity in vivo, which selectively eliminatesthe soluble MUC5AC from plasma. Compared to conventional antibody, the mAb exerted in vivo efficacy by simultaneously engineering both pH-dependent antigen binding, to mimic the pH-dependent receptor-ligand binding of such endocytic receptors, and increased FcRn binding affinity at neutral pH, to mimic the cell-bound form of the receptors.
Gene Expression
Normal Tissue
Figure 1 High expression in stomach 1
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40615/124256_A_6_1_val_selected.jpg
Normal Tissue
Figure 2 Low expression in liver
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40615/124256_A_9_4_val_selected.jpg
Normal Tissue
Figure 3 Stomach
Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40615/124256_A_3_1.jpg
RNA Expression
Figure 4 RNA cell line category: Group enriched (A549, OE19)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000215182-MUC5AC
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Specifications
- Immunogen
- M1 mucin preparation from the fluid of an ovarian mucinous cyst.
- Host Species
- Mouse
- Type
- Mouse IgG1 kappa
- Specificity
- Human MUC5AC
- Species Reactivity
- Human
- Applications
- Antigen-Sweeping In Vivo.
Product Property
- Purification
- Protein A/G purified
- Purity
- >95%
- Format
- Liquid
- Buffer
- PBS only
- Preservative
- None
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1696z | Mouse Anti-MUC5AC Recombinant Antibody (clone 28C10) | FC, IF, IHC | Mouse IgG1, κ |
| MOB-1265CT | Recombinant Mouse anti-Human MUC5AC Monoclonal antibody (2-24N2) | ELISA, ICC, IHC-Fr, IHC-P, WB | |
| HPAB-0566-YJ | Mouse Anti-MUC5AC Recombinant Antibody (HPAB-0566-YJ) | WB, IHC, ELISA | Mouse IgG1 |
| MOB-0116F | Mouse Anti-MUC5AC Recombinant Antibody (MOB-0116F) | IHC-P, IF | Mouse IgG |
| MOB-0117F | Mouse Anti-MUC5AC Recombinant Antibody (MOB-0117F) | IHC-P, IF | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-200 | Anti-Human MUC5AC Recombinant Antibody (TAB-200) | IP, IF, FuncS, FC, Neut, ELISA, ICC | IgG1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-404MZ | Mouse Anti-MUC5AC Recombinant Antibody (TAB-404MZ) | ELISA, Inhib, IHC, IA | Mouse IgG |
| TAB-404MZ-S(P) | Mouse Anti-MUC5AC Recombinant Antibody; scFv Fragment (TAB-404MZ-S(P)) | IHC | Mouse scFv |
| TAB-404MZ-F(E) | Mouse Anti-MUC5AC Recombinant Antibody; Fab Fragment (TAB-404MZ-F(E)) | IHC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-405MZ | Human Anti-MUC5AC Recombinant Antibody (TAB-405MZ) | IF, WB, IHC, IA | Humanized IgG |
| TAB-405MZ-S(P) | Human Anti-MUC5AC Recombinant Antibody; scFv Fragment (TAB-405MZ-S(P)) | IHC | Humanized scFv |
| TAB-406MZ-S(P) | Anti-Human MUC5AC Recombinant Antibody scFv Fragment (VH-1) | FC, ELISA | Humanized antibody |
| TAB-405MZ-F(E) | Human Anti-MUC5AC Recombinant Antibody; Fab Fragment (TAB-405MZ-F(E)) | IHC | Humanized Fab |
| TAB-406MZ-F(E) | Anti-Human MUC5AC Recombinant Antibody Fab Fragment (VH-1) | FC, ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0585CQ | Recombinant Mouse Anti-Human MUC5AC Antibody (19-O Le) | ELISA | IgM |
| EPAF-0586CQ | Recombinant Mouse Anti-Human MUC5AC Antibody (2-25 Le) | ELISA | IgG1 |
| EPAF-0587CQ | Recombinant Mouse Anti-Human MUC5AC Antibody (7 Le) | ELISA | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0340LY-S(P) | Mouse Anti-MUC5AC Recombinant Antibody (clone 58-1066); scfv Fragment | ELISA | Mouse scfv |
| HPAB-AP150-YC-S(P) | Human Anti-MUC5AC Recombinant Antibody (clone Antibody 1); scFv Fragment | ELISA, Cyt | Human scFv |
| HPAB-AP151-YC-S(P) | Human Anti-MUC5AC Recombinant Antibody (clone Antibody 10); scFv Fragment | ELISA, Cyt | Human scFv |
| HPAB-0566-YJ-S(P) | Mouse Anti-MUC5AC Recombinant Antibody; scFv Fragment (HPAB-0566-YJ-S(P)) | WB, ELISA, Inhib, IP, IHC, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0340LY-F(E) | Mouse Anti-MUC5AC Recombinant Antibody (clone 58-1066); Fab Fragment | ELISA | Mouse Fab |
| HPAB-AP150-YC-F(E) | Human Anti-MUC5AC Recombinant Antibody (clone Antibody 1); Fab Fragment | ELISA, Cyt | Human Fab |
| HPAB-AP151-YC-F(E) | Human Anti-MUC5AC Recombinant Antibody (clone Antibody 10); Fab Fragment | ELISA, Cyt | Human Fab |
| HPAB-0566-YJ-F(E) | Mouse Anti-MUC5AC Recombinant Antibody; Fab Fragment (HPAB-0566-YJ-F(E)) | WB, ELISA, Inhib, IP, IHC, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-200 | Afuco™ Anti-MUC5AC ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-200) | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1061 | PE-B*07:02/Human MUC5AC (SPFFLLLLL) MHC Tetramer | FCM, IHC | |
| MHC-CN1062 | APC-B*07:02/Human MUC5AC (SPFFLLLLL) MHC Tetramer | FCM, IHC | |
| MHC-CN1063 | FITC-B*07:02/Human MUC5AC (SPFFLLLLL) MHC Tetramer | FCM, IHC | |
| MHC-CN1064 | B*07:02/Human MUC5AC (SPFFLLLLL) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY330 | Mouse Anti-NHP MUC5AC Recombinant Antibody (clone 45M1) | IHC, ICC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY153 | Human Anti-MUC5AC (clone Ensituximab) scFv-Fc Chimera | ELISA, FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4584 | Anti-MUC5AC Immunohistochemistry Kit | IHC | |
| VS-0525-XY4585 | Anti-Mouse MUC5AC Immunohistochemistry Kit | IHC |
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