Afuco™ Anti-MUC5AC ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-200) (CAT#: AFC-TAB-200)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to 5AC. It is a chimeric monoclonal antibody used in the treatment of cancers.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Normal Tissue
RNA Expression
Figure 1 High expression in stomach 1
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40615/124256_A_6_1_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40615/124256_A_6_1_val_selected.jpg
Figure 2 Low expression in liver
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40615/124256_A_9_4_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40615/124256_A_9_4_val_selected.jpg
Figure 3 Stomach
(Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40615/124256_A_3_1.jpg
(Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40615/124256_A_3_1.jpg
Figure 4 RNA cell line category: Group enriched (A549, OE19)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000215182-MUC5AC
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000215182-MUC5AC
Specifications
- Immunogen
- M1 mucin preparation from the fluid of an ovarian mucinous cyst.
- Host Species
- Chimeric
- Derivation
- Chimeric (mouse/human)
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Applications
- IP, IF, FuncS, FC, Neut, ELISA
- Conjugate
- Unconjugated
- Generic Name
- Ensituximab
- Related Disease
- Colorectal cancers
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- MUC5AC; mucin 5AC, oligomeric mucus/gel-forming; mucin 5, subtypes A and C, tracheobronchial/gastric; mucin-5AC; MUC5; gastric mucin; tracheobronchial mucin; major airway glycoprotein; lewis B blood group antigen
- Gene ID
- 4586
- UniProt ID
- P98088
Related Resources
Please refer to Ensituximab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Ensituximab.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Ensituximab"
DrugMonitor™ Anti-Ensituximab Antibody (VS-1224-YC429)Ensituximab (NEO-102) is a novel chimeric mAb targeting a glycosylated MUC5AC variant, specific to colorectal and pancreatic cancers. The DrugMonitor™ Anti-Ensituximab Antibody (VS-1224-YC429) is an anti-drug antibody (ADA) against Ensituximab. This drug-based antibody is raised in mice immunized with the Ensituximab. The anti-Ensituximab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Ensituximab in samples.
See other products for "MUC5AC"
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-200 | Anti-Human MUC5AC Recombinant Antibody (TAB-200) | IP, IF, FuncS, FC, Neut, ELISA, ICC | IgG1 - kappa |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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