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MUC5AC

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For Research Use Only. Not For Clinical Use.


Background

Mucins are high molecular weight glycoproteins with 80% carbohydrates and 20% core protein. Gastric Mucin 5AC antigen is found in columnar mucus cells of surface gastric epithelium and in goblet cells of the fetal and precancerous colon but not in normal colon. Resurgence of gastric mucin during colonic carcinogenesis is suggestive of either re-expression of the peptide core of gastric mucin in the adult colon or due to changes in the glycosylation pattern of mucin, which expose the hidden Mucin 5AC antigen.
MUC5AC
Predicted location

Secreted

Single cell type specificity

Cell type enriched (Gastric mucus-secreting cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (A549, OE19)

Interaction

Multimeric.

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