Mouse Anti-Musk Recombinant Antibody (VS3-FY2812) (CAT#: VS3-FY2812)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• Human, Mouse and Rat Musk

• Species Reactivity
• Human, Mouse, Rat

• Applications
• Western Blot, Immunohistochemistry

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 96.7 kDa.

• Related Disease
• Fetal Akinesia Deformation Sequence 1 and Myasthenic Syndrome, Congenital, 9, Associated With Acetylcholine Receptor Deficiency

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/2000
  Immunohistochemistry: 1/50-1/200

• Alternative Names
• Muscle Associated Receptor Tyrosine Kinase; Muscle-Specific Tyrosine-Protein Kinase Receptor; Muscle, Skeletal, Receptor Tyrosine Kinase; Muscle-Specific Kinase Receptor; EC 2.7.10.1; Muscle, Skeletal Receptor Tyrosine-Protein Kinase

• Gene ID
• 4593

• UniProt ID
• O15146

• Sequence Similarities
• Belongs to the protein kinase superfamily. Tyr protein kinase family.

• Cellular Localization
• Postsynaptic cell membrane
  Single-pass type I membrane protein

• Post Translation Modifications
• Ubiquitinated by PDZRN3.
  Ubiquitination promotes endocytosis and lysosomal degradation (By similarity).
  (O15146-MUSK_HUMAN)
  Phosphorylated (By similarity).
  Phosphorylation is induced by AGRIN in a LRP4-dependent manner (By similarity).
  Autophosphorylated (PubMed:25029443).
  Autophosphorylation at Tyr-554 is required for interaction with DOK7 which in turn stimulates the phosphorylation and the activation of MUSK (By similarity).
  (O15146-MUSK_HUMAN)
  Neddylated. (O15146-MUSK_HUMAN)
  Glycosylation at Asn222 and Asn338 (NX_O15146 [NX_O15146-1])
  Modification sites at PhosphoSitePlus (O15146)
  Glycosylation from GlyGen (O15146) 3 sites, 1 O-linked glycan (1 site)

• Protein Refseq
• XP_005252052.1; XP_005252053.1; XP_011517010.1; XP_016870223.1

• Function
• May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK.
  DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering.
  May positively regulate Rho family GTPases through FNTA.
  Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression.

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

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