Mouse Anti-Musk Recombinant Antibody (VS3-FY2812)
CAT#: VS3-FY2812
This anti-Musk product is a recombinant monoclonal antibody that has been genetically engineered to specifically target human Musk protein. It cross-reacts with mouse, rat species. The calculated molecular weight of the protein is about 96.7 kDa. This monoclonal antibody proves valuable in disease research related to Fetal Akinesia Deformation Sequence 1 and Myasthenic Syndrome, Congenital, 9, Associated With Acetylcholine Receptor Deficiency. The antibody can be utilized for detection of Musk by Western Blot (1/500-1/2000), Immunohistochemistry (1/50-1/200).
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Group enriched (LHCN-M2, RH-30)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000030304-MUSK
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human, Mouse and Rat Musk
- Species Reactivity
- Human, Mouse, Rat
- Applications
- Western Blot, Immunohistochemistry
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 96.7 kDa.
- Related Disease
- Fetal Akinesia Deformation Sequence 1 and Myasthenic Syndrome, Congenital, 9, Associated With Acetylcholine Receptor Deficiency
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/2000
Immunohistochemistry: 1/50-1/200
Target
- Alternative Names
- Muscle Associated Receptor Tyrosine Kinase; Muscle-Specific Tyrosine-Protein Kinase Receptor; Muscle, Skeletal, Receptor Tyrosine Kinase; Muscle-Specific Kinase Receptor; EC 2.7.10.1; Muscle, Skeletal Receptor Tyrosine-Protein Kinase
- Gene ID
- 4593
- UniProt ID
- O15146
- Sequence Similarities
- Belongs to the protein kinase superfamily. Tyr protein kinase family.
- Cellular Localization
- Postsynaptic cell membrane
Single-pass type I membrane protein
- Post Translation Modifications
- Ubiquitinated by PDZRN3.
Ubiquitination promotes endocytosis and lysosomal degradation (By similarity).
(O15146-MUSK_HUMAN)
Phosphorylated (By similarity).
Phosphorylation is induced by AGRIN in a LRP4-dependent manner (By similarity).
Autophosphorylated (PubMed:25029443).
Autophosphorylation at Tyr-554 is required for interaction with DOK7 which in turn stimulates the phosphorylation and the activation of MUSK (By similarity).
(O15146-MUSK_HUMAN)
Neddylated. (O15146-MUSK_HUMAN)
Glycosylation at Asn222 and Asn338 (NX_O15146 [NX_O15146-1])
Modification sites at PhosphoSitePlus (O15146)
Glycosylation from GlyGen (O15146) 3 sites, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_005252052.1; XP_005252053.1; XP_011517010.1; XP_016870223.1
- Function
- May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK.
DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering.
May positively regulate Rho family GTPases through FNTA.
Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "MUSK"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1123z | Mouse Anti-MUSK Recombinant Antibody (clone 10G6) | ICC, IF, IHC, ELISA | Mouse IgG1 |
| MOB-0075CT | Recombinant Mouse anti-Human MUSK Monoclonal antibody (EML593) | WB | |
| ZG-0296C | Mouse Anti-MUSK Recombinant Antibody (ZG-0296C) | IHC, IF, ELISA | Mouse IgG |
| VS3-WK1033 | Mouse Anti-MUSK Recombinant Antibody (VS3-WK1033) | WB, IHC-P | Mouse IgG1, κ |
| VS7-0425-WR447 | Mouse Anti-MUSK Monoclonal Antibody (VS7-0425-WR447) | IHC-P, IF, ICC, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC923 | AbPlus™ Anti-MUSK Magnetic Beads (VS-0724-YC923) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1124-YJ1 | Human Anti-MUSK Recombinant Autoantibody (clone MuSK1A) | FC, ELISA, IF, Inhib | Human IgG4 lambda |
| VS-1124-YJ2 | Human Anti-MUSK Recombinant Autoantibody (clone MuSK1B) | FC, ELISA, IF, Inhib | Human IgG4 lambda |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4593 | Anti-MUSK Immunohistochemistry Kit | IHC | |
| VS-0525-XY4594 | Anti-Mouse MUSK Immunohistochemistry Kit | IHC |
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