Anti-NES (clone W24V66) Recombinant Antibody Coupled Liposome (VS-1024-FY67)
CAT#: VS-1024-FY67
Liposomes bound to anti-NES antibodies show great potential in the treatment of breast cancer. By coupling antibodies with liposomes, this drug delivery system can target specific receptors (such as HER2), thereby enhancing the effectiveness of targeted therapy and reducing damage to normal cells.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RH-30
Immunofluorescent staining of human cell line RH-30 shows localization to intermediate filaments.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6286/1401_E3_2_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line AF22
Immunofluorescent staining of human cell line AF22 shows localization to intermediate filaments.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26111/1783_C4_5_selected.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to intermediate filaments.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5889/613_B1_1_selected.jpg
Normal Tissue
Figure 4 Spleen
High expression in spleen
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/7007/20723_B_8_4_val_selected.jpg
Normal Tissue
Figure 5 Cerebral cortex
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26111/58753_B_7_5.jpg
Normal Tissue
Figure 6 Colon
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26111/58753_A_7_3.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26111/58753_A_8_5.jpg
Normal Tissue
Figure 8 Heart muscle
Cardiomyocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26111/58753_B_4_6.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (AF22, HUVEC TERT2, LHCN-M2, RH-30, SuSa, WM-115)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000132688-NES
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More Infomation
Specifications
- Potential Clinical Applications
- Breast cancer
Product Composition
- Clone
- W24V66
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- The recombinant mouse antibody exhibits a high specificity in its binding affinity towards human nestin (NES). This characteristic makes it a valuable tool for research and therapeutic applications involving nestin, a protein commonly associated with neural stem cells and various types of tumors.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- NES
- Introduction
- This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells.
- Alternative Names
- Nestin
- Full Name
- Nestin
- Gene ID
- 10763
- UniProt ID
- P48681
- Sequence Similarities
- Belongs to the intermediate filament family.
- Post Translation Modifications
- Constitutively phosphorylated.
This increases during mitosis when the cytoplasmic intermediate filament network is reorganized (By similarity).
( P48681-NEST_HUMAN )
Modification sites at PhosphoSitePlus ( P48681 )
Modification sites at neXtProt ( NX_P48681 )
Glycosylation from GlyGen (P48681) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_006608.1
- Function
- Required for brain and eye development.
Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division.
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
- CAT
- Product Name
See other products for "NES"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1670z | Mouse Anti-NES Recombinant Antibody (clone 28C6) | WB, FC, ICC, IHC, IP | Mouse IgG1 |
| ZG-0550F | Mouse Anti-NES Recombinant Antibody (clone 10C2) | WB, IHC, IP | Mouse IgG1 |
| VS3-CJ983 | Rabbit Anti-NES Recombinant Antibody (VS3-CJ983) | ICC, IF, IHC | Rabbit IgG |
| VS3-WK1880 | Recombinant Rabbit Anti-NES Capture Antibody (clone R65-5M-1) | ELISA | Rabbit IgG |
| VS3-WK1881 | Recombinant Rabbit Anti-NES Detection Antibody (clone R98-7L-2) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0721MZ | Chicken Anti-Nes Polyclonal IgY | ICC, IF, IHC, WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2422 | Hi-Affi™ Recombinant Rabbit Anti-NES Monoclonal Antibody (DS2422AB) | IHC-P, WB | IgG |
| MOR-0108-FY | Rabbit Anti-NES Recombinant Antibody (clone AFY0079) | ICC, IHC, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC623 | AbPlus™ Anti-NES Magnetic Beads (VS-0724-YC623) | IP, Protein Purification | |
| VS-0724-YC624 | AbPlus™ Anti-NES Magnetic Beads (VS-0724-YC624) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC75 | Mouse Anti-NES Recombinant Antibody (VS-0924-YC75) - Cancer Stem Cell Marker | IHC, WB, IF | Mouse IgG1 |
| VS-0924-YC78 | Rabbit Anti-NES Antibody (VS-0924-YC78) - Cancer Stem Cell Marker | IHC, WB, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4792 | Anti-NES Immunohistochemistry Kit | IHC | |
| VS-0525-XY4793 | Anti-Mouse NES Immunohistochemistry Kit | IHC |
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