Anti-NGFR (clone W24V67) Recombinant Antibody Coupled Liposome (VS-1024-FY68) (CAT#: VS-1024-FY68)

• Potential Clinical Applications
• Breast cancer

• Clone
• W24V67

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• The recombinant mouse antibody exhibits a targeted binding affinity specifically for the human nerve growth factor receptor (NGFR). This interaction highlights the antibody's role in recognizing and attaching to the human protein with high specificity, which is crucial for various biomedical applications, including research and therapeutic interventions.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• NGFR

• Introduction
• Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain.

• Alternative Names
• Nerve Growth Factor Receptor; Low Affinity Neurotrophin Receptor P75NTR; Low-Affinity Nerve Growth Factor Receptor; TNFR Superfamily, Member 16; NGF Receptor; Gp80-LNGFR; TNFRSF16; P75 ICD

• Full Name
• Nerve Growth Factor Receptor

• Gene ID
• 4804

• UniProt ID
• P08138

• Cellular Localization
• Cell membrane, Cell projection, Membrane, Synapse

• Post Translation Modifications
• N- and O-glycosylated.
  O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc.
  Phosphorylated on serine residues.

• Protein Refseq
• NP_002498.1

• Function
• Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487).
  Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity).
  Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181).
  Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity).
  Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138).

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