Anti-NOTCH4 Antibody Prodrug, Protease Activated (VS-1025-YC104)
CAT#: VS-1025-YC104
The Anti-NOTCH4 Antibody Prodrug, Protease Activated (VS-1025-YC104) is an antibody prodrug comprised of a recombinant mouse antibody targeting human NOTCH4, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to NOTCH4 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to NOTCH4 effectively. NOTCH4 is a transmembrane receptor that, like other NOTCH family members, can act as an oncogene when aberrantly activated, notably in a subset of breast cancer and T-cell leukemias. Its signaling promotes cell survival and is often associated with the tumor's ability to undergo the epithelial-mesenchymal transition (EMT).
Specifications
- Host Animal
- Mouse
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human NOTCH4
- Target
- NOTCH4
- Species Reactivity
- Human
- Isotype
- IgG1, kappa
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein G purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
- Alternative Names
- INT3
- Gene ID
- 4855
- UniProt ID
- Q99466
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Related Diseases
Breast Cancer
Downloadable Resources
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Datasheet
MSDS
COA
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See other products for "NOTCH4"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2111z | Mouse Anti-NOTCH4 Recombinant Antibody (clone 42C10) | WB, ELISA, IHC, IP | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1787CQ | Recombinant Hamster Anti-Notch4 Antibody (HMN4-14) | BL, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2474 | Hi-Affi™ Recombinant Rabbit Anti-NOTCH4 Monoclonal Antibody (DS2474AB) | WB, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0066-CN | Mouse Anti-NOTCH4 Recombinant Antibody (HPAB-0066-CN) | Neut | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0068-CN | Human Anti-NOTCH4 Recombinant Antibody (HPAB-0068-CN) | Neut, IF | Humanized IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0067-CN | Human Anti-NOTCH4 Recombinant Antibody (HPAB-0067-CN) | Neut | Chimeric (mouse/human) IgG2, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0066-CN-S(P) | Mouse Anti-NOTCH4 Recombinant Antibody; scFv Fragment (HPAB-0066-CN-S(P)) | Neut | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0068-CN-S(P) | Human Anti-NOTCH4 Recombinant Antibody; scFv Fragment (HPAB-0068-CN-S(P)) | Neut, IF | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0066-CN-F(E) | Mouse Anti-NOTCH4 Recombinant Antibody; Fab Fragment (HPAB-0066-CN-F(E)) | Neut | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0068-CN-F(E) | Human Anti-NOTCH4 Recombinant Antibody; Fab Fragment (HPAB-0068-CN-F(E)) | Neut, IF | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0067-CN-F(E) | Human Anti-NOTCH4 Recombinant Antibody; Fab Fragment (HPAB-0067-CN-F(E)) | Neut | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1103-CN | Recombinant Rabbit Anti-NOTCH4 Monoclonal Antibody (JM101-05) | WB, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0194-YC-S(P) | Human Anti-NOTCH4 Recombinant Antibody (clone GLA-S4F18); scFv Fragment | FC, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0194-YC-F(E) | Human Anti-NOTCH4 Recombinant Antibody (clone GLA-S4F18); Fab Fragment | FC, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY162 | Human Anti-NOTCH4 scFv-Fc Chimera (VS-0425-FY162) | FC | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC650 | Recombinant Anti-NOTCH4 Vesicular Antibody, EV Displayed (VS-0425-YC650) | ELISA, FC, Neut, Cell-uptake |
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