Human Anti-NOTCH4 scFv-Fc Chimera (VS-0425-FY162)
CAT#: VS-0425-FY162
NOTCH4 is the fourth NOTCH receptor in this list, with a more restricted expression pattern, notably in endothelial cells and its potential role in vascular development. An anti-NOTCH4 scFv-FC could be useful for studying or targeting NOTCH4-expressing cells.
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human NOTCH4
- Species Reactivity
- Human, Mouse
- Applications
- Flow Cytometry
- Related Disease
- Hematologic Cancer and Schizoaffective Disorder
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Notch 4; INT3; Neurogenic Locus Notch Homolog Protein 4; Notch (Drosophila) Homolog 4; Notch Homolog 4 (Drosophila); Notch Homolog 4; HNotch4
- Gene ID
- 4855
- UniProt ID
- Q99466
- Long Name
- Notch 4
- Sequence Similarities
- Belongs to the NOTCH family.
- Cellular Localization
- Cell membrane, Nucleus
- Post Translation Modifications
- Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form.
Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC).
Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT).
This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane.
Phosphorylated.
Glycosylation at Asn664, Asn714, Asn964, and Asn1143
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 8 sites, 3 O-linked glycans (4 sites)
- Protein Refseq
- NP_004548.3
- Function
- Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination.
Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.
Affects the implementation of differentiation, proliferation and apoptotic programs.
May regulate branching morphogenesis in the developing vascular system.
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Related Diseases
Breast Cancer
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "NOTCH4"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1787CQ | Recombinant Hamster Anti-Notch4 Antibody (HMN4-14) | BL, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2474 | Hi-Affi™ Recombinant Rabbit Anti-NOTCH4 Monoclonal Antibody (DS2474AB) | WB, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0066-CN-S(P) | Mouse Anti-NOTCH4 Recombinant Antibody; scFv Fragment (HPAB-0066-CN-S(P)) | Neut | Mouse scFv |
| HPAB-0068-CN-S(P) | Human Anti-NOTCH4 Recombinant Antibody; scFv Fragment (HPAB-0068-CN-S(P)) | Neut, IF | Human scFv |
| HPAB-N0194-YC-S(P) | Human Anti-NOTCH4 Recombinant Antibody (clone GLA-S4F18); scFv Fragment | FC, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0066-CN-F(E) | Mouse Anti-NOTCH4 Recombinant Antibody; Fab Fragment (HPAB-0066-CN-F(E)) | Neut | Mouse Fab |
| HPAB-0068-CN-F(E) | Human Anti-NOTCH4 Recombinant Antibody; Fab Fragment (HPAB-0068-CN-F(E)) | Neut, IF | Human Fab |
| HPAB-0067-CN-F(E) | Human Anti-NOTCH4 Recombinant Antibody; Fab Fragment (HPAB-0067-CN-F(E)) | Neut | Human Fab |
| HPAB-N0194-YC-F(E) | Human Anti-NOTCH4 Recombinant Antibody (clone GLA-S4F18); Fab Fragment | FC, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0194-YC | Human Anti-NOTCH4 Recombinant Antibody (clone GLA-S4F18) | FC, FuncS | Human IgG |
| VS3-WK529 | Rabbit Anti-NOTCH4 Recombinant Antibody (clone JM101-05) | WB, FC | Rabbit IgG |
| VS3-FY1052 | Recombinant Mouse Anti-NOTCH4 Antibody (clone 1B2B6) | ELISA, ICC, FC | Mouse IgG1 |
| VS3-FY1053 | Recombinant Mouse Anti-NOTCH4 Antibody (clone 6D8D4) | ELISA, IHC, FC | Mouse IgG2a |
| VS3-FY1054 | Recombinant Rabbit Anti-NOTCH4 Antibody (clone R08-8H5) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC650 | Recombinant Anti-NOTCH4 Vesicular Antibody, EV Displayed (VS-0425-YC650) | ELISA, FC, Neut, Cell-uptake |
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