Recombinant Anti-OSM Eliminating Antibody, pH-Sensitive (VS-0625-YC246)
CAT#: VS-0625-YC246
The anti-OSM eliminating antibody is an engineered pH-sensitive antibody against human OSM. OSM is a cytokine regulating tumor cell proliferation and cytokine production. The antibody has a novel OSM-sweeping activity in vivo, which selectively eliminatesthe soluble OSM from plasma. Compared to conventional antibody, the mAb exerted in vivo efficacy by simultaneously engineering both pH-dependent antigen binding, to mimic the pH-dependent receptor-ligand binding of such endocytic receptors, and increased FcRn binding affinity at neutral pH, to mimic the cell-bound form of the receptors.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (HDLM-2, HL-60, HMC-1, Karpas-707, NB-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000099985-OSM
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1 kappa
- Specificity
- Human OSM
- Species Reactivity
- Human
- Applications
- Antigen-Sweeping In Vivo.
Product Property
- Purification
- Protein A/G purified
- Purity
- >95%
- Format
- Liquid
- Buffer
- PBS only
- Preservative
- None
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "OSM"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1474z | Mouse Anti-OSM Recombinant Antibody (clone 25C2) | WB, ELISA, IHC, Neut | Mouse IgG2a |
| MOB-2223MZ | Recombinant Mouse Anti-Human OSM Antibody (clone 28002.42) | ELISA, Neut, WB | Mouse antibody |
| HPAB-0112-CN | Mouse Anti-OSM Recombinant Antibody (clone 15E10) | ELISA | Mouse IgG2a, κ |
| HPAB-0278CQ | Mouse Anti-OSM Recombinant Antibody (HPAB-0278CQ) | ELISA, IHC, FuncS, Inhib | Mouse IgG1, κ |
| HPAB-0279CQ | Human Anti-OSM Recombinant Antibody (HPAB-0279CQ) | ELISA, IHC, FuncS, Inhib | Human IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1815CQ | Recombinant Rat Anti-Osm Antibody (CBL660) | Neut | IgG2b |
| NEUT-1816CQ | Recombinant Mouse Anti-OSM Antibody (17001.31) | ELISA, WB, Neut | IgG2a |
| NEUT-1817CQ | Recombinant Mouse Anti-OSM Antibody (CBL423) | WB, ELISA(Cap), Neut | IgG2a |
| NEUT-1818CQ | Recombinant Mouse Anti-OSM Antibody (CBL424) | CyTOF, ICFC, Neut | IgG2a |
| NEUT-1819CQ | Recombinant Mouse Anti-OSM Antibody (CBL150) | Neut, WB | IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2557 | Hi-Affi™ Recombinant Rabbit Anti-OSM Monoclonal Antibody (DS2557AB) | WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0112-CN-S(P) | Mouse Anti-OSM Recombinant Antibody (clone 15E10); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0113-CN-S(P) | Mouse Anti-OSM Recombinant Antibody (clone 10D3); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0114-CN-S(P) | Human Anti-OSM Recombinant Antibody (clone B3L2); scFv Fragment | ELISA | Human scFv |
| HPAB-0278CQ-S(P) | Mouse Anti-OSM Recombinant Antibody; scFv Fragment (HPAB-0278CQ-S(P)) | ELISA, IHC, FuncS, Inhib | Mouse scFv |
| HPAB-0279CQ-S(P) | Human Anti-OSM Recombinant Antibody; scFv Fragment (HPAB-0279CQ-S(P)) | ELISA, IHC, FuncS, Inhib | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0112-CN-F(E) | Mouse Anti-OSM Recombinant Antibody (clone 15E10); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0113-CN-F(E) | Mouse Anti-OSM Recombinant Antibody (clone 10D3); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0114-CN-F(E) | Human Anti-OSM Recombinant Antibody (clone B3L2); Fab Fragment | ELISA | Human Fab |
| HPAB-0278CQ-F(E) | Mouse Anti-OSM Recombinant Antibody; Fab Fragment (HPAB-0278CQ-F(E)) | ELISA, IHC, FuncS, Inhib | Mouse Fab |
| HPAB-0279CQ-F(E) | Human Anti-OSM Recombinant Antibody; Fab Fragment (HPAB-0279CQ-F(E)) | ELISA, IHC, FuncS, Inhib | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5110 | Anti-OSM Immunohistochemistry Kit | IHC | |
| VS-0525-XY5111 | Anti-Mouse OSM Immunohistochemistry Kit | IHC |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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