Rabbit Anti-p53 Recombinant Antibody (VS3-FY2827)
CAT#: VS3-FY2827
The anti-p53 antibody is a rabbit recombinant monoclonal antibody that has been intricately crafted to target the mouse p53 protein. This monoclonal antibody proves valuable in disease research related to Li-Fraumeni Syndrome and Papilloma Of Choroid Plexus. It is recommended for detection of target protein by Immunoprecipitation (1/20), Western Blot (1/500-1/1000) and Immunocytochemistry (1/50-1/200).
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Mouse p53
- Species Reactivity
- Mouse
- Applications
- Western Blot, Immunocytochemistry, Immunoprecipitation
- Conjugate
- Unconjugated, FITC
- Related Disease
- Li-Fraumeni Syndrome and Papilloma Of Choroid Plexus
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunoprecipitation: 1/20
Western Blot: 1/500-1/1000
Immunocytochemistry: 1/50-1/200
Target
- Alternative Names
- GH11591p; P53 tumor suppressor-like protein; P53-like regulator of apoptosis and cell cycle; Transcription factor; Transcription factor p53; p53, isoform A; p53, isoform C; p53; prac
- Gene ID
- 22059
- UniProt ID
- P02340
- Sequence Similarities
- Belongs to the p53 family.
- Cellular Localization
- Cytoplasm
Nucleus
Nucleus, PML body
Endoplasmic reticulum
Mitochondrion matrix
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
- Post Translation Modifications
- Sumoylated with SUMO1.
Sumoylated at Lys-386 by UBC9.
(P04637-P53_HUMAN)
Ubiquitination at Lys24, Lys164, Lys101, Lys132, Lys291, Lys292, Lys305, Lys320, and Lys321 (NX_P04637 [NX_P04637-1])
Modification sites at PhosphoSitePlus (P04637)
Glycosylation from GlyGen (P04637) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001119584.1; NP_001119585.1; NP_001119586.1; NP_001119587.1
- Function
- Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type (PubMed:11025664, 12524540, 12810724, 15186775, 15340061, 17317671, 17349958, 19556538, 20673990, 20959462, 22726440, 24051492, 9840937, 24652652).
Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process (PubMed:11025664, 12524540, 12810724, 15186775, 15340061, 17317671, 17349958, 19556538, 20673990, 20959462, 22726440, 24051492, 9840937, 24652652).
One of the activated genes is an inhibitor of cyclin-dependent kinases.
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Related Diseases
Bladder Cancer
Endometrial Cancer
Gastric Cancer
Prostate Cancer
Amyotrophic Lateral Sclerosis
Related Signaling Pathways
p53 Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
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