Anti-PDGFRB Antibody Prodrug, Protease Activated (VS-1025-YC215)

Name: Anti-PDGFRB Antibody Prodrug, Protease Activated (VS-1025-YC215)
SKU: VS-1025-YC215
Rating: 5 (1 reviews)

CAT#: VS-1025-YC215

The Anti-PDGFRB Antibody Prodrug, Protease Activated (VS-1025-YC215) is an antibody prodrug comprised of a recombinant human antibody targeting human PDGFRB, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to PDGFRB protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to PDGFRB effectively. PDGFRB (Platelet-Derived Growth Factor Receptor Beta) is a receptor tyrosine kinase that promotes tumor growth by regulating the tumor microenvironment. Its signaling drives the proliferation and recruitment of supporting cells (pericytes and fibroblasts), and it is a target for broad-spectrum TKIs.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line ASC TERT1

Immunofluorescent staining of human cell line ASC TERT1 shows localization to the Golgi apparatus & vesicles.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28499/1774_C4_13_cr5950fa3646972_selected.jpg

Normal Tissue Figure 2 Testis

Pachytene spermatocytes Staining: Low Intensity: Moderate Quantity: <25% Peritubular cells Staining: High Intensity: Strong Quantity: 75%-25% Spermatogonia cells Staining: Low Intensity: Moderate

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3842/10254_A_4_6.jpg

Normal Tissue Figure 3 Placenta

Decidual cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Trophoblastic cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3842/10254_A_2_7.jpg

Normal Tissue Figure 4 Cerebral cortex

Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3842/10254_B_9_5.jpg

Normal Tissue Figure 5 Liver

Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3842/10254_A_9_4.jpg

Normal Tissue Figure 6 Kidney

Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3842/10254_A_8_5.jpg

RNA Expression Figure 7 RNA cell line category: Group enriched (ASC diff, ASC TERT1)

Cell lines ordered by descending RNA expression order

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000113721-PDGFRB

❮

❯

Specifications

Host Animal
Human

Applications
In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay

Specificity
Human PDGFRB

Target
PDGFRB

Species Reactivity
Human

Isotype
IgG

Masking Approach
Affinity mask

Mask
A synthetic peptide

Protease Cleavable Linker
MMP-cleavable linker

Protease Substrate
MMPs

Purification
Protein A purified

Buffer
PBS, pH 7.4

Preservative
No preservatives

Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Target

Introduction
IMC-2C5 binds to both human and mouse PDGFRβ. And it is involved in the treatment of a broad range of human cancers.

Alternative Names
PDGFRB

Gene ID
5159

UniProt ID
P01139

REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS

Inquiry

Navs

Customer Review

There are currently no Customer reviews or questions for VS-1025-YC215. Click the button above to contact us or submit your feedback about this product.

Submit Your Publication

Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Datasheet

Datasheet - VS-1025-YC215.pdf

MSDS

MSDS - VS-1025-YC215.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

See other products for "PDGFRB"

Select a product category from the dropdown menu below to view related products.

CAT	Product Name	Application	Type
MOB-1734z	Mouse Anti-PDGFRB Recombinant Antibody (clone 1H11)	ELISA, IF, WB	Mouse IgG1

CAT	Product Name	Application	Type
TAB-706CL	Anti-Human PDGFRB Antibody (IMC-2C5), Research Grade Biosimilar	Inhib, FuncS	Antibody

CAT	Product Name	Application	Type
TAB-0988CL	Human Anti-PDGFRB Recombinant Antibody (TAB-0988CL)	ELISA	Human IgG

CAT	Product Name	Application	Type
TAB-0989CL	Human Anti-PDGFRB Recombinant Antibody (TAB-0989CL)	ELISA	Human IgG

CAT	Product Name	Application	Type
TAB-0990CL	Human Anti-PDGFRB Recombinant Antibody (TAB-0990CL)	ELISA	Human IgG

CAT	Product Name	Application	Type
TAB-0991CL	Human Anti-PDGFRB Recombinant Antibody (TAB-0991CL)	ELISA	Human IgG

CAT	Product Name	Application	Type
MOB-2107MZ	Recombinant Mouse Anti-Human PDGFRB Antibody (clone 29B3), PE-Conjugated	FC	Mouse antibody

CAT	Product Name	Application	Type
NEUT-1850CQ	Recombinant Rat Anti-Pdgfrb Antibody (APB5)	FC, FuncS, Neut	IgG2a, κ

CAT	Product Name	Application	Type
MOR-2638	Hi-Affi™ Recombinant Rabbit Anti-PDGFRB Monoclonal Antibody (DS2638AB)	WB	IgG

CAT	Product Name	Application	Type
MOB-141CQ	Human Anti-Pdgfrb Antibody Fab Fragment (1B3)	FC, WB, Neut	Human Fab

CAT	Product Name	Application	Type
HPAB-0281CQ	Human Anti-PDGFRB Recombinant Antibody (clone 1B3)	ELISA, FC, WB, Neut	Human IgG

CAT	Product Name	Application	Type
HPAB-0281CQ-F(E)	Human Anti-PDGFRB Recombinant Antibody (clone 1B3); Fab Fragment	ELISA, FC, WB, Neut	Human Fab

CAT	Product Name	Application	Type
HPAB-0281CQ-S(P)	Human Anti-PDGFRB Recombinant Antibody (clone 1B3); scFv Fragment	ELISA, FC, WB, Neut	Human scFv

CAT	Product Name	Application	Type
MRO-1193-CN	Recombinant Rabbit Anti-PDGFRB Monoclonal Antibody (CBACN-438)	WB, IHC, IP	Rabbit IgG

CAT	Product Name	Application	Type
MRO-2112-CN	Rabbit Anti-PDGFRB Polyclonal Antibody (MRO-2112-CN)	WB, IF, IHC, FC	Rabbit IgG

CAT	Product Name	Application	Type
AFC-TAB-448CQ	Afuco™ Anti-PDGFRB Recombinant Antibody (AFC-TAB-448CQ), ADCC Enhanced	ELISA, IHC, FC, IP, IF, FuncS	Human IgG1, κ

CAT	Product Name	Application	Type
HPAB-N0227-YC-S(P)	Human Anti-PDGFRB Recombinant Antibody (clone PFH2); scFv Fragment	Block	Human scFv

CAT	Product Name	Application	Type
HPAB-N0227-YC-F(E)	Human Anti-PDGFRB Recombinant Antibody (clone PFH2); Fab Fragment	Block	Human Fab

CAT	Product Name	Application	Type
HPAB-1110-CN-S(P)	Mouse Anti-PDGFRB Recombinant Antibody; scFv Fragment (HPAB-1110-CN-S(P))	ELISA	Mouse scFv

CAT	Product Name	Application	Type
HPAB-1111-CN-S(P)	Human Anti-PDGFRB Recombinant Antibody; scFv Fragment (HPAB-1111-CN-S(P))	ELISA	Human scFv

CAT	Product Name	Application	Type
HPAB-1112-CN-S(P)	Human Anti-PDGFRB Recombinant Antibody; scFv Fragment (HPAB-1112-CN-S(P))	ELISA	Human scFv

CAT	Product Name	Application	Type
HPAB-1110-CN-F(E)	Mouse Anti-PDGFRB Recombinant Antibody; Fab Fragment (HPAB-1110-CN-F(E))	ELISA	Mouse Fab

CAT	Product Name	Application	Type
HPAB-1111-CN-F(E)	Human Anti-PDGFRB Recombinant Antibody; Fab Fragment (HPAB-1111-CN-F(E))	ELISA	Human Fab

CAT	Product Name	Application	Type
VS-0424-XY209	AbPlus™ Anti-PDGFRB Magnetic Beads (CBACN-438)	IP, Protein Purification

CAT	Product Name	Application	Type
VS-0125-FY27	Human Anti-PDGFRB scFv-Fc Chimera (VS-0125-FY27)	Inhib	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0325-FY47	Human Anti-PDGFRB scFv-Fc Chimera (VS-0325-FY47)	ELISA	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS13-YC884	CytoStream™ Rabbit Anti-PDGFRB Recombinant Antibody (VS13-YC884)	WB, IHC-P, ICC, IF, FC	Rabbit IgG

CAT	Product Name	Application	Type
VS-0325-XY1599	Anti-PDGFRB Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0425-YC588	Recombinant Anti-PDGFRB Vesicular Antibody, EV Displayed (VS-0425-YC588)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-XY5278	Anti-Mouse PDGFRB Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-YC143	Recombinant Anti-PDGFRB (3rd domain x 4th domain) Biparatopic Antibody, Tandem scFv (Clone muM4TS.22 x Clone muM4TS.11)	ELISA, Neut	Tandem scFv

CAT	Product Name	Application	Type
VS-0825-YC284	SmartAb™ Recombinant Anti-PDGFRB pH-dependent Antibody (VS-0825-YC284)	Inhibition	Human IgG

Specific Inquiry

Add to compare

See Our Custom Production in Action

Figure 1 Anti-HBV Recombinant Antibody (TAB-147) in SDS-PAGE

Download the full case study

Popular Products

Anti-Human EGFR Recombinant Antibody (Panitumumab) (CAT# TAB-020)
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC

Anti-Human 4-1BB Recombinant Antibody (TAB-179) (CAT# TAB-179)
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC

Chimeric (Mouse/Human) Anti-SDC1 Recombinant Antibody (TAB-197) (CAT# TAB-197)
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC

Anti-Human Nogo-A Recombinant Antibody (TAB-903) (CAT# TAB-903)
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC

Anti-Human IL17RA Recombinant Antibody (TAB-217) (CAT# TAB-217)
Application: WB, ELISA, FC, IP, FuncS, IF, Neut

Anti-C. difficile Toxin A Recombinant Antibody (TAB-716) (CAT# TAB-716)
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC

Anti-Human folate receptor 1 Recombinant Antibody (TAB-113) (CAT# TAB-113)
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC

Anti-Human Integrin alpha 4 beta 7 Recombinant Antibody (Etrolizumab) (CAT# TAB-135)
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC

Anti-Human CD18 Recombinant Antibody F(ab')₂ Fragment (TAB-154-F(E)) (CAT# TAB-154-F(E))
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC

Anti-Human IL5 Recombinant Antibody (TAB-031) (CAT# TAB-031)
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC

Chimeric (Mouse/Human) Anti-TNFRSF8 Recombinant Antibody (TAB-153) (CAT# TAB-153)
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC

Anti-Human CD70 Recombinant Antibody (Vorsetuzumab) (CAT# TAB-H76)
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC

Human Anti-Human CD27 Recombinant Antibody (TAB-H74) (CAT# TAB-H74)
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC

Human Anti-CD40 Recombinant Antibody (TAB-126CL) (CAT# TAB-126CL)
Application: Block, Cyt, FuncS, Inhib

Anti-Human FLT3 Recombinant Antibody (IMC-EB10) (CAT# TAB-291CL)
Application: WB, IHC, FC, Cyt, ELISA

Abciximab (CAT# TP-100CL)
Application:

Human Anti-Human VEGF Recombinant Antibody; Fab Fragment (TP-104CL) (CAT# TP-104CL)
Application:

Rabbit Anti-Hypusine Recombinant Antibody (PABL-202) (CAT# PABL-202)
Application: WB, ELISA, FuncS

Human Anti-VEGF Recombinant Antibody (clone B20-4) (CAT# PABC-131)
Application: ELISA, Neut, Block

Recombinant Human Anti-VEEV E2 Antibody (3B4C-4) (CAT# PABL-742)
Application: Neut

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.