Anti-Human PDGFRB Antibody (IMC-2C5), Research Grade Biosimilar
CAT#: TAB-706CL
Recombinant Human monoclonal antibody expressed in CHO binding to Human PDGFRB. IMC-2C5 binds to both human and mouse PDGFRβ. And it is involved in the treatment of a broad range of human cancers.
Published Data
Gene Expression
Inhib
Figure 1 IMC-2C5 antibody inhibits tumor growth as a monotherapy agent in xenograft models.
Shen, J., Vil, M. D., Prewett, M., Damoci, C., Zhang, H., Li, H., ... & Bassi, R. (2009). Development of a fully human anti-PDGFRβ antibody that suppresses growth of human tumor xenografts and enhances antitumor activity of an anti-VEGFR2 antibody. Neoplasia (New York, NY), 11(6), 594.
FuncS
Figure 2 IMC-2C5 enhances the antitumor activity of an anti-VEGFR2 antibody, DC101.
Athymic nude mice bearing xenografted tumors of 200 to 300 mm size were randomized and divided into four treatment groups (n = 12 per group) and were treated by i.p. injections three times a week with USP saline, IMC-2C5 (40 mg/kg), DC101 (40 mg/kg), or IMC-2C5 plus DC101 (40 mg/kg each).
Shen, J., Vil, M. D., Prewett, M., Damoci, C., Zhang, H., Li, H., ... & Bassi, R. (2009). Development of a fully human anti-PDGFRβ antibody that suppresses growth of human tumor xenografts and enhances antitumor activity of an anti-VEGFR2 antibody. Neoplasia (New York, NY), 11(6), 594.
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Subcellular Location
Figure 1 IF staining of human cell line ASC TERT1
Immunofluorescent staining of human cell line ASC TERT1 shows localization to the Golgi apparatus & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28499/1774_C4_13_cr5950fa3646972_selected.jpg
Normal Tissue
Figure 2 Testis
Pachytene spermatocytes Staining: Low Intensity: Moderate Quantity: <25% Peritubular cells Staining: High Intensity: Strong Quantity: 75%-25% Spermatogonia cells Staining: Low Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3842/10254_A_4_6.jpg
Normal Tissue
Figure 3 Placenta
Decidual cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Trophoblastic cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3842/10254_A_2_7.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3842/10254_B_9_5.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3842/10254_A_9_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3842/10254_A_8_5.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (ASC diff, ASC TERT1)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000113721-PDGFRB
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Specifications
- Host Species
- Human
- Derivation
- Human
- Type
- Antibody
- Species Reactivity
- Human
- Applications
- Inhib, FuncS
- Related Disease
- Solid Tumors
Product Property
- Purity
- >90% assessed by SDS-PAGE
- Storage
- Short Term Storage: 4°C
Long Term Storage: -20°C
Applications
- Application Notes
- This antibody has been tested for use in Functional Assay and Inhibition. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. be carefully titrated in specific assays.
Target
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(Creative Biolabs Cat# TAB-706CL, RRID: AB_3111985)
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
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