Recombinant Human monoclonal antibody expressed in CHO binding to Human PDGFRB. IMC-2C5 binds to both human and mouse PDGFRβ. And it is involved in the treatment of a broad range of human cancers.
Figure 1 IMC-2C5 antibody inhibits tumor growth as a monotherapy agent in xenograft models.
Shen, J., Vil, M. D., Prewett, M., Damoci, C., Zhang, H., Li, H., ... & Bassi, R. (2009). Development of a fully human anti-PDGFRβ antibody that suppresses growth of human tumor xenografts and enhances antitumor activity of an anti-VEGFR2 antibody. Neoplasia (New York, NY), 11(6), 594.
Figure 2 IMC-2C5 enhances the antitumor activity of an anti-VEGFR2 antibody, DC101.
Athymic nude mice bearing xenografted tumors of 200 to 300 mm size were randomized and divided into four treatment groups (n = 12 per group) and were treated by i.p. injections three times a week with USP saline, IMC-2C5 (40 mg/kg), DC101 (40 mg/kg), or IMC-2C5 plus DC101 (40 mg/kg each).
Shen, J., Vil, M. D., Prewett, M., Damoci, C., Zhang, H., Li, H., ... & Bassi, R. (2009). Development of a fully human anti-PDGFRβ antibody that suppresses growth of human tumor xenografts and enhances antitumor activity of an anti-VEGFR2 antibody. Neoplasia (New York, NY), 11(6), 594.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1734z | Mouse Anti-PDGFRB Recombinant Antibody (clone 1H11) | ELISA, IF, WB | Mouse IgG1 |
MRO-1193-CN | Recombinant Rabbit Anti-PDGFRB Monoclonal Antibody (CBACN-438) | WB, IHC, IP | Rabbit IgG |
HPAB-S0105-YC | Mouse Anti-PDGFRB Recombinant Antibody (clone muM4TS.11) | ELISA, Neut | Mouse IgG |
HPAB-S0106-YC | Human Anti-PDGFRB Recombinant Antibody (clone HuM4TS.11) | ELISA, Neut | Humanized IgG |
HPAB-S0107-YC | Mouse Anti-PDGFRB Recombinant Antibody (clone muM4TS.22) | ELISA, Neut | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0988CL | Human Anti-PDGFRB Recombinant Antibody (TAB-0988CL) | ELISA | Human IgG |
TAB-0989CL | Human Anti-PDGFRB Recombinant Antibody (TAB-0989CL) | ELISA | Human IgG |
TAB-0990CL | Human Anti-PDGFRB Recombinant Antibody (TAB-0990CL) | ELISA | Human IgG |
TAB-0991CL | Human Anti-PDGFRB Recombinant Antibody (TAB-0991CL) | ELISA | Human IgG |
TAB-0988CL-S(P) | Human Anti-PDGFRB Recombinant Antibody; scFv Fragment (TAB-0988CL-S(P)) | ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1850CQ | Recombinant Rat Anti-Pdgfrb Antibody (APB5) | FC, FuncS, Neut | IgG2a, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-2638 | Hi-Affi™ Recombinant Rabbit Anti-PDGFRB Monoclonal Antibody (DS2638AB) | WB | IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-141CQ | Human Anti-Pdgfrb Antibody Fab Fragment (1B3) | FC, WB, Neut | Human Fab |
HPAB-0281CQ-F(E) | Human Anti-PDGFRB Recombinant Antibody (clone 1B3); Fab Fragment | ELISA, FC, WB, Neut | Human Fab |
HPAB-S0105-YC-F(E) | Mouse Anti-PDGFRB Recombinant Antibody (clone muM4TS.11); Fab Fragment | ELISA, Neut | Mouse Fab |
HPAB-S0106-YC-F(E) | Human Anti-PDGFRB Recombinant Antibody (clone HuM4TS.11); Fab Fragment | ELISA, Neut | Humanized Fab |
HPAB-S0107-YC-F(E) | Mouse Anti-PDGFRB Recombinant Antibody (clone muM4TS.22); Fab Fragment | ELISA, Neut | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0281CQ-S(P) | Human Anti-PDGFRB Recombinant Antibody (clone 1B3); scFv Fragment | ELISA, FC, WB, Neut | Human scFv |
HPAB-N0227-YC-S(P) | Human Anti-PDGFRB Recombinant Antibody (clone PFH2); scFv Fragment | Block | Human scFv |
HPAB-1110-CN-S(P) | Mouse Anti-PDGFRB Recombinant Antibody; scFv Fragment (HPAB-1110-CN-S(P)) | ELISA | Mouse scFv |
HPAB-1111-CN-S(P) | Human Anti-PDGFRB Recombinant Antibody; scFv Fragment (HPAB-1111-CN-S(P)) | ELISA | Human scFv |
HPAB-S0108-YC-S(P) | Human Anti-PDGFRB Recombinant Antibody (clone HuM4TS.22); scFv Fragment | ELISA, Neut | Humanized scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-448CQ | Afuco™ Anti-PDGFRB Recombinant Antibody (AFC-TAB-448CQ), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | Human IgG1, κ |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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