Mouse Anti-PDPN Recombinant Antibody (clone D2-40) (CAT#: HPAB-0087-YJ)
This product is a mouse antibody that recognizes human MA2 (gp36, podoplanin, Aggrus, T1A-2). Podoplanin (PDPN) is an O-glycosylated transmembrane glycoprotein that is selectively expressed by, and is a marker of, lymphatic endothelial cells. The antibody D2-40 has been shown to be a sensitive and specific antibody for the detection of lymphatic endothelium in different malignancies, and functions in the routine evaluation of lymphatic invasion in esophageal cancer. Mab D2-40 was reported to be an excellent immunohistochemical marker of cutaneous Kaposi's sarcomas and may play a role in the differential diagnosis of epithelioid malignant mesothelioma versus adenocarcinoma.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line EFO-21
(Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane & cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7949/1907_B7_4_selected.jpg
(Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane & cell junctions.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/7949/1907_B7_4_selected.jpg
Figure 2 Colon
(Endothelial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8376/24701_A_9_3.jpg
(Endothelial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8376/24701_A_9_3.jpg
Figure 3 Testis
(Leydig cells Staining: Low Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8376/24701_A_4_6.jpg
(Leydig cells Staining: Low Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/8376/24701_A_4_6.jpg
Figure 4 RNA cell line category: Cell line enhanced (AF22, EFO-21, HAP1, HHSteC, NTERA-2, SuSa, TIME)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000162493-PDPN
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000162493-PDPN
Specifications
- Immunogen
- Resected tissue from dysgeminoma of the ovary
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human PDPN
- Species Reactivity
- Human
- Clone
- D2-40
- Applications
- IHC, IF, WB
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The antibody D2-40 has been reported in applications of Immunohistochemistry, Immunofluorescence, Western Blot. It's recommended that the optimal antibody concentration, dilution, incubition time etc. be carefully titrated in specific assays.
Target
- Alternative Names
- Podoplanin; Lung Type I Cell Membrane Associated Glycoprotein; Glycoprotein 36; PA2.26 Antigen; T1-Alpha; AGGRUS; GP36; T1A; Lung Type-I Cell Membrane-Associated Glycoprotein (T1A-2); Glycoprotein, 36-KD; HT1alpha-1; M2A; D2-40
- Gene ID
- 10630
- UniProt ID
- Q86YL7
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1598z | Mouse Anti-PDPN Recombinant Antibody (clone 26C11) | WB, FC, ICC, IF, IHC | Mouse IgG1, κ |
| MOB-1618CT | Recombinant Mouse anti-Human PDPN Monoclonal antibody (29I6) | FC, ICC/IF, IHC-Fr, IHC-P, WB | |
| MOB-066CQ | Golden Syrian Hamster Anti-Podoplanin Antibody | WB, FC, ICC/IF, IHC-Fr, IHC-P | Golden Syrian Hamster IgG |
| FAMAB-1296CQ | Mouse Anti-PDPN Recombinant Antibody (clone PMab-2) | WB, FC, IHC | Mouse IgG1 |
| ZG-0507U | Rabbit Anti-PDPN Recombinant Antibody (clone 4E6) | ELISA | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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