Mouse Anti-PGF Recombinant Antibody (clone 5D11D4) (CAT#: HPAB-0615YY)
This product is a recombinant Mouse antibody that recognizes (both natural and recombinant) Mouse PGF.
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Inhib
Figure 1 Inhibition of PlGF Leads to Regression of Medulloblastoma.
Murine-specific anti-PlGF Ab 5D11D4 (amPlGF) shows significantly tumor size inhibition effect in Smo/Smo spontaneous model of medulloblastoma. Measured in cross-section.
Snuderl, M., Batista, A., Kirkpatrick, N. D., de Almodovar, C. R., Riedemann, L., Walsh, E. C., ... & Knevels, E. (2013). Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. Cell, 152(5), 1065-1076.
Inhib
Figure 2 Inhibition of stromal PlGF in D283-MED or D341-MED tumors by anti-mouse PlGF (amPlGF) 5D11D4 led to delayed growth and stabilization of the tumor.
In the D283-MED model, treatment with amPlGF 5D11D4 from day 1 after implantation (D283 amPlGFP, prevention trial) led to a growth delay similar to shPlGF inhibition.
Snuderl, M., Batista, A., Kirkpatrick, N. D., de Almodovar, C. R., Riedemann, L., Walsh, E. C., ... & Knevels, E. (2013). Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. Cell, 152(5), 1065-1076.
Specifications
- Immunogen
- hPlGF1
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Mouse
- Species Reactivity
- Mouse
- Clone
- 5D11D4
- Applications
- Inhib
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The PGF antibody has been reported in applications of Inhibition.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Single Domain Antibody Products
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Fab Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-022 | Recombinant Anti-Mouse Pgf VHH Single Domain Antibody | WB, ELISA, IHC, FC, FuncS | Llama VHH |
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Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# HPAB-0615YY, RRID: AB_3111403)
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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