Mouse Anti-PLD2 Recombinant Antibody (PL60)
CAT#: VS-0326-YC60
The anti-PLD2 recombinant antibody (PL60) reacts with human PLD2. PLD2 is a membrane-associated enzyme that hydrolyzes phosphatidylcholine to produce phosphatidic acid (PA). PA acts as a second messenger that regulates vesicle trafficking, cytoskeletal remodeling, and the activation of mTOR. PLD2 signaling is involved in cell migration and is often upregulated in invasive cancer phenotypes. The anti-PLD2 antibody (PL60) has been tested in Enzyme-linked Immunosorbent Assay (ELISA), Immunocytochemistry (ICC), Immunohistochemistry (IHC) and Flow Cytometry (FC).
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IHC staining of human colon
Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13397/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13397/41684_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Peripheral nerve/ganglion
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13397/41684_A_7_3.jpg
Normal Tissue
Figure 4 Liver
Cholangiocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: Not detected
Intensity: Weak
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13397/41684_A_7_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13397/41684_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Elongated or late spermatids
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Leydig cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13397/41684_A_4_6.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000129219-PLD2/subcellular
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human PLD2
- Species Reactivity
- Human
- Clone
- PL60
- Applications
- ELISA, ICC, IHC, FC
- Conjugate
- The unconjugated, Biotin and FITC formats are available.
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity purified
- Format
- Liquid
- Buffer
- PBS
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Applications
- Application Notes
- IHC (1/200-1/1000), ICC (1/200-1/1000), ELISA (1/5000-1/20000), FC (1/200-1/400)
Target
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Related Signaling Pathways
Ras Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "PLD2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0173CT | Recombinant Mouse anti-Human PLD2 Monoclonal antibody (EML2191) | WB |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS7-0425-WR632 | Mouse Anti-PLD2 Recombinant Antibody (clone 7E4D9) | IHC, ICC, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS7-0425-WR633 | Mouse Anti-PLD2 Recombinant Antibody (clone 8G1G2) | FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5471 | Anti-PLD2 Immunohistochemistry Kit | IHC |
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