Anti-PPP4C (clone W24V72) Recombinant Antibody Coupled Liposome (VS-1024-FY73) (CAT#: VS-1024-FY73)

• Potential Clinical Applications
• Breast cancer

• Clone
• W24V72

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• The recombinant mouse antibody exhibits a highly specific binding affinity for human PPP4C, a protein integral to several cellular processes, including the regulation of protein phosphatase activities. This antibody has been engineered to recognize and bind selectively to the human PPP4C protein, which plays a crucial role in various signaling pathways and cellular mechanisms.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• PPP4C

• Introduction
• Protein phosphatase 4C may be involved in microtubule organization. It binds 1 iron ion and 1 manganese ion per subunit. PP4 consists of a catalytic subunit PPP4C and a regulatory subunit. PPP4R1 and belongs to the PPP phosphatase family, PPX subfamily.

• Alternative Names
• PP-X; PP4; PP4C; PPH3; PPP4; PPX

• Full Name
• protein phosphatase 4 catalytic subunit

• Gene ID
• 5531

• UniProt ID
• P60510

• Sequence Similarities
• Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.

• Cellular Localization
• Nucleus, Cytoplasm, Cytoskeleton

• Post Translation Modifications
• Methylation at the C-terminal Leu-307 is critical for interactions with regulatory subunits and functions in DNA repair.

• Protein Refseq
• NP_001290432.1; NP_001290433.1; NP_001290435.1

• Function
• Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity).
  In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.

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