Rabbit Anti-PPP4C Recombinant Antibody (clone R05-4F9)
CAT#: VS3-FY1608
The R05-4F9 recombinant monoclonal antibody is specific for human PPP4C. It cross-reacts with mouse, rat. This PPP4C antibody was verified by western blot analysis of PPX in K562, C6, 3T3, Hela lysates. Western blot demonstrated that R05-4F9 recognized a target protein with a molecular weight of 35 kDa.
Tested Data
WB
Figure 1 Anti-PPP4C Antibody (VS3-FY1608) in WB.
The PPX expression in K562, C6, 3T3, Hela lysates were detected using the anti-PPP4C by western blot assay.
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Specifications
- Immunogen
- Recombinant human PPP4C protein
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat PPP4C
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R05-4F9
- Applications
- Western Blot
- MW
- The calculated weight of the target protein is approximately 35 kDa, while the observed molecular weight stands at 35 kDa.
- Related Disease
- Contagious Pustular Dermatitis and Severe Combined Immunodeficiency
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- PP-X, PP4, PP4C, PPH3, PPP4, PPX
- Gene ID
- 5531
- UniProt ID
- P60510
- Sequence Similarities
- Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.
- Cellular Localization
- Nucleus, Cytoplasm, Cytoskeleton
- Post Translation Modifications
- Methylation at the C-terminal Leu-307 is critical for interactions with regulatory subunits and functions in DNA repair.
- Protein Refseq
- NP_001290432.1; NP_001290433.1; NP_001290435.1
- Function
- Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity).
In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "PPP4C"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1628CT | Recombinant Mouse anti-Human PPP4C Monoclonal antibody (3) | ELISA, WB | |
| ZG-0393C | Mouse Anti-PPP4C Recombinant Antibody (ZG-0393C) | WB, IHC, IF | Mouse IgG |
| VS3-CJ75 | Mouse Anti-PPP4C Recombinant Antibody (VS3-CJ75) | WB, ELISA | Mouse IgG |
| VS4-CJ86 | Recombinant Mouse Anti-PPP4C Antibody (VS4-CJ86) | ELISA, WB, IHC, ICC | Mouse IgG2a |
| VS7-0425-WR670 | Mouse Anti-PPP4C Recombinant Antibody (VS7-0425-WR670) | WB, IHC-P, IF, ICC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1005 | AbPlus™ Anti-PPP4C Magnetic Beads (VS-0724-YC1005) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1728 | Anti-PPP4C Immunohistochemistry Kit | IHC |
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