Rabbit Anti-PRDX3 Recombinant Antibody (clone R07-3I3) (CAT#: VS3-FY2061)

• Immunogen
• Synthetic peptide of human peroxiredoxin 3/PRDX3

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human PRDX3

• Species Reactivity
• Human

• Clone
• R07-3I3

• Applications
• Western Blot, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunofluorescence, Immunoprecipitation

• MW
• The calculated weight of the target protein is approximately 28 kDa, while the observed molecular weight stands at 28 kDa.

• Related Disease
• Spinocerebellar Ataxia, Autosomal Recessive 32 and Corneal Dystrophy, Punctiform And Polychromatic Pre-Descemet

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% glycerol, 0.05% BSA

• Preservative
• 0.01% Sodium azide

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunohistochemistry: 1/50-1/100
  Immunofluorescence: 1/50-1/200
  Immunoprecipitation: 1/20

• Alternative Names
• PRDX3; AOP-1; AOP1; HBC189; MER5; PRO1748; SP-22; prx-III; peroxiredoxin 3

• Gene ID
• 10935

• UniProt ID
• P30048

• Sequence Similarities
• Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

• Cellular Localization
• Cytoplasm, Endosome, Mitochondrion

• Post Translation Modifications
• Phosphorylated by LRRK2; phosphorylation reduces perodixase activity., The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond., S-palmitoylated.

• Protein Refseq
• NP_001289201.1; NP_006784.1;

• Function
• Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
  Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol.
  Required for the maintenance of physical strength (By similarity).

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

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