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  • Rabbit Anti-PSIP1 Recombinant Antibody (clone R52-3N-5)

Rabbit Anti-PSIP1 Recombinant Antibody (clone R52-3N-5) (CAT#: VS3-XY3478)

This is a recombinant rabbit antibody targeting the PSIP1 (PC4 and SRSF1 interacting protein 1), which may play an important role in lens epithelial to fiber cell terminal differentiation. PSIP1 may also play a protective role during stress-induced apoptosis. It specifically reacts with human PSIP1. It has been reported for use in Western Blot, Immunohistochemistry-Paraffin, Immunocytochemistry or Immunofluorescence.


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Subcellular Location and Protein Expression
Figure 1 IHC staining of human cerebral cortex
Figure 1 IHC staining of human cerebral cortex
(Immunohistochemical staining of human cerebral cortex shows strong nuclear as well as cytoplasmic positivity in neuronal and glial cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19697/ihc_selected.jpg
Figure 2 IF staining of human cell line A-431
Figure 2 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19697/178_B4_1_red_green.jpg
Figure 3 IF staining of human cell line U-2 OS
Figure 3 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19697/247_B4_1_red_green.jpg
Figure 4 IF staining of human cell line U-251 MG
Figure 4 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19697/177_B4_1_red_green.jpg
Normal Tissue
Figure 5 Cerebral cortex
Figure 5 Cerebral cortex
(Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Nuclear
Glial cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Neuronal cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19697/46099_B_9_5.jpg
Figure 6 Colon
Figure 6 Colon
(Endocrine cells
Staining:High
Intensity: Strong
Endothelial cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Enterocytes
Staining:High
Intensity: Strong
Quantity:>75%
Fibroblasts
Staining:High
Intensity: Strong
Goblet cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Mucosal lymphoid cells
Staining:High
Intensity: Strong
Quantity:>75%
Peripheral nerve/ganglion
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19697/46212_A_8_3.jpg
Figure 7 Liver
Figure 7 Liver
(Cholangiocytes
Staining:High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Hepatocytes
Staining:High
Intensity: Strong
Quantity:>75%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19697/46212_A_9_4.jpg
Figure 8 Kidney
Figure 8 Kidney
(Cells in glomeruli
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Nuclear
Cells in tubules
Staining:High
Intensity: Strong
Quantity:>75%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19697/46212_A_8_5.jpg
Figure 9 Testis
Figure 9 Testis
(Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Pachytene spermatocytes
Staining:High
Intensity: Strong
Quantity:>75%
Peritubular cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Preleptotene spermatocytes
Staining:High
Intensity: Strong
Quantity:>75%
Round or early spermatids
Staining:High
Intensity: Strong
Quantity:>75%
Sertoli cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Spermatogonia cells
Staining:High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19697/46212_A_6_6.jpg
Figure 10 Lymph node
Figure 10 Lymph node
(Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Nuclear
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19697/46212_A_7_8.jpg
RNA Expression
Figure 11 RNA cell line category: Cell line enhanced (HEL)
Figure 11 RNA cell line category: Cell line enhanced (HEL)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000164985-PSIP1

Specifications

  • Host Species
  • Rabbit
  • Type
  • Rabbit IgG
  • Specificity
  • Human PSIP1
  • Species Reactivity
  • Human
  • Clone
  • R52-3N-5
  • Applications
  • WB, IHC-P, ICC, IF
  • Related Disease
  • Interstitial Cystitis; Laryngeal Small Cell Carcinoma

Product Property

  • Clonality
  • Monoclonal
  • Aggregation
  • < 5%
  • Format
  • Liquid
  • Buffer
  • PBS (pH 7.4), 150 mM NaCl and 50% glycerol
  • Preservative
  • 0.02% sodium azide
  • Storage
  • Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Shipping
  • Ice packs

Applications

  • Application Notes
  • WB: 1/500-1/1000
    IHC: 1/100-1/200
    IF: 1/50-1/200

Target

  • Alternative Names
  • p52; p75; PAIP; DFS70; LEDGF; PSIP2
  • Long Name
  • PC4 and SRSF1 interacting protein 1
  • Cellular Localization
  • Nucleus
  • Post Translation Modifications
  • Citrullinated by PADI4. (O75475-PSIP1_HUMAN)
    Ubiquitination at Lys6, Lys75, Lys364, Lys407, Lys415, Lys422, Lys424, and Lys442 (NX_O75475 [NX_O75475-1])
    Modification sites at PhosphoSitePlus (O75475)
    Glycosylation from GlyGen (O75475) 2 sites, 2 O-linked glycans (2 sites)
  • Function
  • Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis.
    Involved in particular in lens epithelial cell gene regulation and stress responses.
    May play an important role in lens epithelial to fiber cell terminal differentiation.
    May play a protective role during stress-induced apoptosis.

Recommended Products

Isotype Control

Recommended Dilution Buffer

Secondary Antibody

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "PSIP1"

Recombinant Antibody

CAT Product Name Application Type
DrMAB-487 Recombinant Human Anti-Human PSIP1 Antibody, clone D484 ELISA, IP-MS IgG
MOB-1701CT Recombinant Mouse anti-Human PSIP1 Monoclonal antibody (7F5) ICC/IF, IHC-P, WB
VS3-XY1312 Mouse Anti-PSIP1 Recombinant Antibody (clone 6E4) ELISA, WB, IHC, ICC Mouse IgG1

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-2886 Hi-Affi™ Recombinant Rabbit Anti-PSIP1 Monoclonal Antibody (DS2886AB) WB IgG

Single-domain Antibody

CAT Product Name Application Type
PABC-550 Recombinant Human Anti-PSIP1 Single Domain Antibody (PABC-550) ELISA, WB, Inhib Human VHH

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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