Mouse Anti-Rapgef4 Recombinant Antibody (Ra953)
CAT#: VS-0326-YC953
The anti-Rapgef4 recombinant antibody (Ra953) reacts with mouse Rapgef4. Rapgef4 (EPAC2) is a Guanine Nucleotide Exchange Factor for Rap GTPases that is directly activated by cAMP. It bypasses the PKA pathway to regulate processes such as insulin secretion in pancreatic β-cells and synaptic plasticity. EPAC2 signaling coordinates the spatial and temporal effects of cAMP on exocytosis and the cytoskeleton. The anti-Rapgef4 antibody (Ra953) has been tested in Immunohistochemistry (IHC).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RT4
Immunofluorescent staining of human cell line RT4 shows localization to focal adhesion sites.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28968/1375_H11_2_selected.jpg
Normal Tissue
Figure 2 IHC staining of human placenta
Immunohistochemical staining of human placenta shows strong cytoplasmic positivity in trophoblastic cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/28968/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Glial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4388/12013_B_8_5.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4388/12013_A_9_3.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4388/12013_A_8_4.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4388/12013_A_4_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4388/12013_A_9_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (Karpas-707, SCLC-21H, U-266/70, U-266/84)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000091428-RAPGEF4
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG2a
- Specificity
- Mouse Rapgef4
- Species Reactivity
- Mouse
- Clone
- Ra953
- Applications
- IHC
- Conjugate
- The unconjugated, Biotin and FITC formats are available.
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity purified
- Format
- Liquid
- Buffer
- PBS
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Applications
- Application Notes
- IHC (1/25-1/200)
Target
- Alternative Names
- Rap Guanine Nucleotide Exchange Factor 4; CAMP-Regulated Guanine Nucleotide Exchange Factor II; Exchange Protein Directly Activated By CAMP 2; RAP Guanine-Nucleotide-Exchange Factor (GEF) 4; Rap Guanine Nucleotide Exchange Factor (GEF) 4; Exchange Factor Directly Activated By CAMP 2; CAMP-GEFII;
- UniProt ID
- Q9EQZ6
- Long Name
- Rap Guanine Nucleotide Exchange Factor 4
- Post Translation Modifications
- Unmodified
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "RAPGEF4"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1391MZ | Recombinant Mouse Anti-Human RAPGEF4 Antibody | WB | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS14-YC527 | AibGenesis™ Rabbit Anti-RAPGEF4 Recombinant Antibody (AibG-Rb-AP324) | WB | Rabbit IgG |
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