Mouse Anti-RRM1 Recombinant Antibody (clone 5F12E6)
CAT#: VS7-0425-WR797
This product is a mouse IgG2a antibody that binds to human RRM1. The antibody 5F12E6 recognizes specific amino acid domain of human RRM1 (AA: 541-792). It can be used for WB and FC assay.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/57265/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human tonsil
Immunohistochemical staining of human tonsil shows cytoplasmic positivity in germinal center.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/57265/137943_A_5_8_selected.jpg
Normal Tissue
Figure 3 Tonsil.
High expression in tonsil
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_A_6_8_val_selected.jpg
Normal Tissue
Figure 4 Testis
Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Spermatogonia cells Staining: Low Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_A_4_6.jpg
Normal Tissue
Figure 5 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_A_8_8.jpg
Normal Tissue
Figure 6 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_B_8_5.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167325-RRM1
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Specifications
- Immunogen
- Recombinant human RRM1 (AA: 541-792) fragment expressed in E. Coli.
- Host Species
- Mouse
- Type
- Mouse IgG2a
- Specificity
- Human RRM1
- Species Reactivity
- Human
- Clone
- 5F12E6
- Molecule Class
- Ribonucleotide Reductase
- Applications
- WB, FC
- Conjugate
- Unconjugated
- Related Disease
- Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 6 (PEOB6)
Product Property
- Clonality
- Monoclonal
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- 0.05% sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:500 - 1:2000
Flow Cytometry: 1:200 - 1:400
Enzyme-linked Immunosorbent Assay: 1:10000
Target
- Alternative Names
- RRM1; Ribonucleotide Reductase M1 Polypeptide; R1; Ribonucleotide Reductase, R1 Subunit; Ribonucleotide Reductase M1; RIR1; EC 1.17.4.1; Ribonucleotide Reductase Large Subunit
- Gene ID
- 6240
- UniProt ID
- P23921
- Long Name
- Ribonucleotide Reductase Catalytic Subunit M1
- Cellular Localization
- Cytoplasm
- Post Translation Modifications
- Acetylation; Disulfide bond; Phosphoprotein
- Protein Refseq
- NP_001024.1
- Function
- Allosteric enzyme; Oxidoreductase
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0822MZ | Recombinant Mouse Anti-Human RRM1 Antibody | WB | Mouse antibody |
| ZG-0194U | Mouse Anti-RRM1 Recombinant Antibody (clone 3D6H5) | ELISA, IHC | Mouse IgG |
| VS3-FY2865 | Anti-RRM1 Recombinant Antibody (VS3-FY2865) | WB, IHC, ICC, IP, FC, ELISA | IgG |
| VS13-YC1020 | Rabbit Anti-RRM1 Recombinant Antibody (VS13-YC1020) | WB, IHC-Fr, IHC-P, ICC, IF, IP | Rabbit IgG |
| VS7-0425-WR796 | Mouse Anti-RRM1 Recombinant Antibody (clone 2D6D8) | WB, IHC, FC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3131 | Hi-Affi™ Recombinant Rabbit Anti-RRM1 Monoclonal Antibody (DS3131AB) | IHC-P | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1925 | PE-A*02:01/Human RRM1 (GLYSGVTTV) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1972 | Anti-RRM1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6243 | Anti-Mouse RRM1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6242 | Anti-Human RRM1 Immunohistochemistry Kit | IHC |
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