Mouse Anti-RRM1 Recombinant Antibody (clone 5F12E6) (CAT#: VS7-0425-WR797)
This product is a mouse IgG2a antibody that binds to human RRM1. The antibody 5F12E6 recognizes specific amino acid domain of human RRM1 (AA: 541-792). It can be used for WB and FC assay.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/57265/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/57265/if_selected.jpg
Figure 2 IHC staining of human tonsil
(Immunohistochemical staining of human tonsil shows cytoplasmic positivity in germinal center.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/57265/137943_A_5_8_selected.jpg
(Immunohistochemical staining of human tonsil shows cytoplasmic positivity in germinal center.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/57265/137943_A_5_8_selected.jpg
Figure 3 Tonsil.
(High expression in tonsil)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_A_6_8_val_selected.jpg
(High expression in tonsil)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_A_6_8_val_selected.jpg
Figure 4 Testis
(Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Spermatogonia cells Staining: Low Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_A_4_6.jpg
(Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Spermatogonia cells Staining: Low Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_A_4_6.jpg
Figure 5 Lymph node
(Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_A_8_8.jpg
(Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_A_8_8.jpg
Figure 6 Cerebral cortex
(Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_B_8_5.jpg
(Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/22093/58719_B_8_5.jpg
Figure 7 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167325-RRM1
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000167325-RRM1
Specifications
- Immunogen
- Recombinant human RRM1 (AA: 541-792) fragment expressed in E. Coli.
- Host Species
- Mouse
- Type
- Mouse IgG2a
- Specificity
- Human RRM1
- Species Reactivity
- Human
- Clone
- 5F12E6
- Molecule Class
- Ribonucleotide Reductase
- Applications
- WB, FC
- Conjugate
- Unconjugated
- Related Disease
- Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 6 (PEOB6)
Product Property
- Clonality
- Monoclonal
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- 0.05% sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:500 - 1:2000
Flow Cytometry: 1:200 - 1:400
Enzyme-linked Immunosorbent Assay: 1:10000
Target
- Alternative Names
- RRM1; Ribonucleotide Reductase M1 Polypeptide; R1; Ribonucleotide Reductase, R1 Subunit; Ribonucleotide Reductase M1; RIR1; EC 1.17.4.1; Ribonucleotide Reductase Large Subunit
- Gene ID
- 6240
- UniProt ID
- P23921
- Long Name
- Ribonucleotide Reductase Catalytic Subunit M1
- Cellular Localization
- Cytoplasm
- Post Translation Modifications
- Acetylation; Disulfide bond; Phosphoprotein
- Protein Refseq
- NP_001024.1
- Function
- Allosteric enzyme; Oxidoreductase
Recommended Products
Isotype Control
Secondary Antibody
Reconstitution Buffer
Recommended Dilution Buffer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| MOB-2841z | Mouse Anti-RRM1 Recombinant Antibody (clone 41D1) | WB, ICC, IF, IHC | Mouse IgG1 |
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| MRO-1349-CN | Recombinant Rabbit Anti-RRM1 Monoclonal Antibody (JB09-43) | WB, IHC, FC, IP | Rabbit IgG |
| VS3-FY2865 | Anti-RRM1 Recombinant Antibody (VS3-FY2865) | WB, IHC, ICC, IP, FC, ELISA | IgG |
| VS13-YC1020 | Rabbit Anti-RRM1 Recombinant Antibody (VS13-YC1020) | WB, IHC-Fr, IHC-P, ICC, IF, IP | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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