Human Anti-RSV Recombinant Antibody (clone RB1) (CAT#: HPAB-3048LY)

This product is an antibody that recognizes RSV. The antibody RB1 can be used for immunoassay techniques such as: ELISA, Neut.

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Neut

Figure 1 In vitro binding and neutralization.

The neutralization activity of RB1 against laboratory strains HMPV A and B with MPE8 control antibody. Assays were run in triplicate, showing error bars at mean with standard deviation (SD).

Tang, A., Chen, Z., Cox, K. S., Su, H. P., Callahan, C., Fridman, A., ... & Touch, S. (2019). A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein. Nature communications, 10(1), 1-13.

FuncS

Figure 2 Efficacy of RB1 in the lower respiratory tracts of cotton rats.

Cotton rats were administered RB1 by intramuscular injection with a dose titration and blood was collected for evaluation of serum antibody concentrations the following day. Immediately after blood sample collections, each animal was challenged intra-nasally with 1x 10̶⁵ pfu of RSV A2 or B 18537 strains. Four days post-challenge, animals were euthanized, blood collected for evaluation of antibody concentrations, and lung tissue collected to assess mAb efficacy by measuring RSV infectious titers in the pulmonary tissues.

Tang, A., Chen, Z., Cox, K. S., Su, H. P., Callahan, C., Fridman, A., ... & Touch, S. (2019). A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein. Nature communications, 10(1), 1-13.


Specifications

  • Host Species
  • Human
  • Derivation
  • Human
  • Type
  • Human IgG1
  • Specificity
  • Human RSV
  • Species Reactivity
  • Human
  • Clone
  • RB1
  • Applications
  • Neut, FuncS

Applications

  • Application Notes
  • This antibody has been reported for use in Neutralization and Functional Assay. It's recommended that the optimal antibody concentration, dilution, incubition time, etc. should be carefully titrated in specific assays.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

See other products for "RSV"


For research use only. Not intended for any clinical use.

* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
IAImmunoassay
IBImmunoblotting
ICCImmunocytochemistry
IDImmunodiffusion
IFImmunofluorescence
IHCImmunohistochemistry
IHC-FrImmunohistochemistry-Frozen
IHC-PImmunohistochemistry-Paraffin
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
Live cell imagingLive cell imaging
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
MultiplexMultiplex bead-based assay
NeutNeutralization
PPProtein Purification
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
TCTissue Culture
TBTurbidimetry
WBWestern Blot

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