Human Anti-RSV Recombinant Antibody (clone B21m) (CAT#: PABL-693)
Recombinant Human Antibody (B21m) is capable of binding to RSV, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-RSV mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-RSV proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition.
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Figure 1 Surface plasmon resonance (SPR) analysis using the ProteOn XPR36 in co-injection mode IgG1 variants.
(A) wild-type (WT); (B) N434A or (C) N434Y were diluted 1:5 in a concentration series from 1000 to 1.6 nM, injected over rat FcRn for 1 min in PBS-TE (pH 6.0) and followed immediately by a co-injection of PBS-TE (pH 7.4) without mAb for 3 min.
Cooper, P. R. , Kliwinski, C. M. , Perkinson, R. A. , Ragwan, E. , Mabus, J. R. , & Powers, G. D. , et al. (2014). The contribution of cell surface fcrn in monoclonal antibody serum uptake from the intestine in suckling rat pups. Frontiers in Pharmacology, 5.
Figure 2 Greatest serum levels of IgG measured when administered at site with greatest rat FcRn mRNA expression.
(A) Serum levels of the WT mAb were measured after 90 min following administration at the proximal small intestine (S.I; duodenal region) and at the distal S.I (ileum region) in suckling rat pups (n = 6). A one-way ANOVA followed by Bonferroni's multiple comparison test was carried out versus respective WT. (B) mRNA expression of rat FcRn, assessed using reverse transcription polymerase chain reaction (RT-PCR), from mucosal scrapings of proximal and distal small intestine, and proximal and distal colon. Data shown is fold change over proximal colon which had the lowest level of FcRn mRNA).
Cooper, P. R. , Kliwinski, C. M. , Perkinson, R. A. , Ragwan, E. , Mabus, J. R. , & Powers, G. D. , et al. (2014). The contribution of cell surface fcrn in monoclonal antibody serum uptake from the intestine in suckling rat pups. Frontiers in Pharmacology, 5.
Specifications
- Immunogen
- Respiratory syncytial virus
- Host Species
- Human
- Type
- Human IgG
- Specificity
- RSV
- Clone
- B21m
- Applications
- WB, IF, FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- RSV; Respiratory syncytial virus
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-098 | Anti-RSV Recombinant Antibody (TAB-098) | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG1 - kappa |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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