Rabbit Anti-SATB2 Recombinant Antibody (clone R06-6D8) (CAT#: VS3-XY3494)
The antibody is a recombinant rabbit antibody against SATB2 (SATB homeobox 2), which acts as a docking site for several chromatin remodeling enzymes. SATB2 also acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. This antibody specifically reacts with human, mouse and rat SATB2. It has been detected by Western Blot, Immunohistochemistry-Paraffin, Immunocytochemistry or Immunofluorescence.
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/29543/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/29543/if_selected.jpg
Figure 2 Cerebral cortex
(Neuronal cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67751/152042_B_9_5.jpg
(Neuronal cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67751/152042_B_9_5.jpg
Figure 3 Colon
(Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67751/152042_A_9_3.jpg
(Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67751/152042_A_9_3.jpg
Figure 4 Rectum
(Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67751/152042_A_4_3.jpg
(Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67751/152042_A_4_3.jpg
Figure 5 Kidney
(Proximal tubules (cell body)
Staining: Low
Intensity: Moderate
Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67751/152042_A_8_5.jpg
(Proximal tubules (cell body)
Staining: Low
Intensity: Moderate
Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67751/152042_A_8_5.jpg
Figure 6 RNA cell line category: Cell line enhanced (HEL, K-562, THP-1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000119042-SATB2/subcellular
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000119042-SATB2/subcellular
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat SATB2
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R06-6D8
- Applications
- WB, IHC-P, ICC, IF
- Related Disease
- Glass Syndrome; Cleft Palate, Isolated
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
Target
- Alternative Names
- GLSS; DEL2Q32Q33; C2DELq32q33
- Gene ID
- 23314
- UniProt ID
- Q9UPW6
- Long Name
- SATB homeobox 2
- Cellular Localization
- Nucleus matrix
- Post Translation Modifications
- Sumoylated by PIAS1.
Sumoylation promotes nuclear localization, but represses transcription factor activity.
(Q9UPW6-SATB2_HUMAN)
Ubiquitination at Lys184 (NX_Q9UPW6 [NX_Q9UPW6-1])
Modification sites at PhosphoSitePlus (Q9UPW6)
Glycosylation from GlyGen (Q9UPW6) 3 sites, 1 O-linked glycan (3 sites)
- Protein Refseq
- XP_047299731.1
- Function
- Binds to DNA, at nuclear matrix- or scaffold-associated regions.
Thought to recognize the sugar-phosphate structure of double-stranded DNA.
Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling.
Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers.
Required for the initiation of the upper-layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-888 | Recombinant Anti-human SATB2 Antibody | WB, ELISA, IHC, FuncS | IgG |
| MHH-888 | Recombinant Human Anti-human SATB2 Antibody | IF, FC, Biosensors, FuncS | IgG |
| MOB-2453CT | Recombinant Mouse anti-Human SATB2 Monoclonal antibody (nBcdbn) | IP, ICC/IF, IHC-FoFr, WB, IHC-Fr, IHC-P | |
| MRO-1366-CN | Recombinant Rabbit Anti-SATB2 Monoclonal Antibody (JM52-44) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-FY1624 | Rabbit Anti-SATB2 Recombinant Antibody (clone R02-1H5) | WB | Rabbit IgG |
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