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    Rabbit Anti-SF3B1 Recombinant Antibody (VS3-FY2871) (CAT#: VS3-FY2871)

    This anti-SF3B1 antibody is a rabbit recombinant monoclonal antibody. It has been specifically designed to target the human SF3B1 protein. It cross-reacts with mouse, hamster, rat species. The monoclonal antibody can be used in the area of Myelodysplastic Syndrome and Acquired Idiopathic Sideroblastic Anemia.

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    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
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    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Normal Tissue
    Figure 1 IHC staining of human salivary gland
    Figure 1 IHC staining of human salivary gland
    (Immunohistochemical staining of human salivary gland shows strong nuclear and cytoplasmic positivity in glandular cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/50275/115976_B_2_1_selected.jpg
    Figure 2 Cerebral cortex
    Figure 2 Cerebral cortex
    (Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/50275/115976_B_9_5.jpg
    Figure 3 Colon
    Figure 3 Colon
    (Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/50275/115976_A_8_3.jpg
    Figure 4 Liver
    Figure 4 Liver
    (Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/50275/115976_A_9_4.jpg
    Figure 5 Kidney
    Figure 5 Kidney
    (Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/50275/115976_A_7_5.jpg
    Figure 6 Testis
    Figure 6 Testis
    (Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/50275/115976_A_4_6.jpg
    Figure 7 Skin
    Figure 7 Skin
    (Keratinocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Langerhans Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Melanocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/50275/115976_B_7_1.jpg
    Figure 8 Lymph node
    Figure 8 Lymph node
    (Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/50275/115976_A_9_8.jpg
    RNA Expression
    Figure 9 RNA cell line category: Low cell line specificity
    Figure 9 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000115524-SF3B1

    Specifications

    • Host Species
    • Rabbit
    • Type
    • Rabbit IgG
    • Specificity
    • Human, Mouse, Hamster, Rat SF3B1
    • Species Reactivity
    • Human, Mouse, Rat, Hamster
    • Applications
    • Western Blot, Immunohistochemistry, Immunocytochemistry
    • Conjugate
    • Unconjugated, FITC
    • Related Disease
    • Myelodysplastic Syndrome and Acquired Idiopathic Sideroblastic Anemia

    Product Property

    • Clonality
    • Monoclonal Antibody
    • Format
    • Liquid
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

    Applications

    • Application Notes
    • Western Blot: 1/500-1/1000
      Immunohistochemistry: 1/50-1/100
      Immunocytochemistry: 1/50-1/200

    Target

    • Alternative Names
    • Splicing Factor 3b Subunit 1; Splicing Factor 3b, Subunit 1, 155kDa; Spliceosome-Associated Protein 155; SF3b155; SAP155; Pre-MRNA Splicing Factor SF3b, 155 KDa Subunit; Pre-MRNA-Splicing Factor SF3b 155 KDa Subunit; Splicing Factor 3b, Subunit 1, 155kD
    • Sequence Similarities
    • Belongs to the SF3B1 family.
    • Cellular Localization
    • Nucleus, Nucleus speckle
    • Post Translation Modifications
    • Phosphorylated.
      Phosphorylation occurs concomitantly with the splicing catalytic steps.
      Phosphorylation on Thr-244, Thr-248 and Thr-313 by cyclin-dependent kinases promotes interaction with PPP1R8 during mitosis.
      Citrullinated by PADI4. (O75533-SF3B1_HUMAN)
      Ubiquitination at Lys182, Lys195, Lys793, Lys816, Lys926, Lys1014, Lys1102, and Lys1292 (NX_O75533 [NX_O75533-1])
      Modification sites at PhosphoSitePlus (O75533)
      Glycosylation from GlyGen (O75533) 4 sites, 1 O-linked glycan (4 sites)
    • Function
    • May also be involved in the assembly of the 'E' complex (PubMed:10882114).
      Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs.

    Recommended Products

    Secondary Antibody

    Isotype Control

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "SF3B1"

    Select a product category from the dropdown menu below to view related products.
    Please select product type
    Rabbit Monoclonal Antibody Products IgG Antibody Products Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
    CAT Product Name Application Type
    MOR-3240 Hi-Affi™ Recombinant Rabbit Anti-SF3B1 Monoclonal Antibody (DS3240AB) WB IgG

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