Rabbit Anti-SIN3A Recombinant Antibody (clone R08-4C2) (CAT#: VS3-XY3506)
It is a recombinant rabbit antibody binding to SIN3A (SIN3 transcription regulator family member A), which acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. The antibody specifically reacts with human, mouse and rat SIN3A. This antibody has been determined using Western Blot, Immunohistochemistry-Paraffin, Flow cytometry, Immunocytochemistry or Immunofluorescence.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4506/672_F12_6_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4506/672_F12_6_selected.jpg
Figure 2 IHC staining of human bone marrow
(Immunohistochemical staining of human bone marrow shows strong nuclear positivity in bone marrow poietic cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4506/ihc_selected.jpg
(Immunohistochemical staining of human bone marrow shows strong nuclear positivity in bone marrow poietic cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4506/ihc_selected.jpg
Figure 3 Cerebral cortex
(Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/62123/139641_B_8_5.jpg
(Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/62123/139641_B_8_5.jpg
Figure 4 Colon
(Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/62123/139641_A_8_3.jpg
(Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/62123/139641_A_8_3.jpg
Figure 5 Kidney
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/62123/139641_A_9_5.jpg
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/62123/139641_A_9_5.jpg
Figure 6 Testis
(Leydig cells Staining: Low Intensity: Weak Quantity:>75% Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/62123/139641_A_6_6.jpg
(Leydig cells Staining: Low Intensity: Weak Quantity:>75% Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/62123/139641_A_6_6.jpg
Figure 7 Skin
(Fibroblasts Staining: Low Intensity: Weak Quantity:>75% Location: Nuclear Keratinocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Langerhans Staining: Low Intensity: Weak Quantity:>75% Location: Nuclear Melanocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/62123/139641_B_7_1.jpg
(Fibroblasts Staining: Low Intensity: Weak Quantity:>75% Location: Nuclear Keratinocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Langerhans Staining: Low Intensity: Weak Quantity:>75% Location: Nuclear Melanocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/62123/139641_B_7_1.jpg
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000169375-SIN3A
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000169375-SIN3A
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat SIN3A
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R08-4C2
- Applications
- WB, IHC-P, ICC, IF, FC
- Related Disease
- Witteveen-Kolk Syndrome; Chromosome 15Q24 Deletion Syndrome
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
FC: 1/50-1/100
Target
- Alternative Names
- WITKOS; DEL15Q24; CHR15DELq24
- Gene ID
- 25942
- UniProt ID
- Q96ST3
- Long Name
- SIN3 transcription regulator family member A
- Cellular Localization
- Nucleus, nucleolus
- Post Translation Modifications
- Ubiquitination at Lys343, Lys727, and Lys747 (NX_Q96ST3 [NX_Q96ST3-1])
Modification sites at PhosphoSitePlus (Q96ST3)
Glycosylation from GlyGen (Q96ST3) 10 sites, 2 O-linked glycans (10 sites)
- Protein Refseq
- XP_006720529.1
- Function
- Acts as a transcriptional repressor.
Corepressor for REST.
Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities.
Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA.
Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Rabbit Monoclonal Antibody Products
IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3265 | Hi-Affi™ Recombinant Rabbit Anti-SIN3A Monoclonal Antibody (DS3265AB) | WB, IHC, ICC | IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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