Rabbit Anti-SIN3A Recombinant Antibody (clone R08-4C2)
CAT#: VS3-XY3506
It is a recombinant rabbit antibody binding to SIN3A (SIN3 transcription regulator family member A), which acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. The antibody specifically reacts with human, mouse and rat SIN3A. This antibody has been determined using Western Blot, Immunohistochemistry-Paraffin, Flow cytometry, Immunocytochemistry or Immunofluorescence.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4506/672_F12_6_selected.jpg
Normal Tissue
Figure 2 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows strong nuclear positivity in bone marrow poietic cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4506/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/62123/139641_B_8_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/62123/139641_A_8_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/62123/139641_A_9_5.jpg
Normal Tissue
Figure 6 Testis
Leydig cells Staining: Low Intensity: Weak Quantity:>75% Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/62123/139641_A_6_6.jpg
Normal Tissue
Figure 7 Skin
Fibroblasts Staining: Low Intensity: Weak Quantity:>75% Location: Nuclear Keratinocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Langerhans Staining: Low Intensity: Weak Quantity:>75% Location: Nuclear Melanocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/62123/139641_B_7_1.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000169375-SIN3A
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat SIN3A
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R08-4C2
- Applications
- WB, IHC-P, ICC, IF, FC
- Related Disease
- Witteveen-Kolk Syndrome; Chromosome 15Q24 Deletion Syndrome
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
FC: 1/50-1/100
Target
- Alternative Names
- WITKOS; DEL15Q24; CHR15DELq24
- Gene ID
- 25942
- UniProt ID
- Q96ST3
- Long Name
- SIN3 transcription regulator family member A
- Cellular Localization
- Nucleus, nucleolus
- Post Translation Modifications
- Ubiquitination at Lys343, Lys727, and Lys747 (NX_Q96ST3 [NX_Q96ST3-1])
Modification sites at PhosphoSitePlus (Q96ST3)
Glycosylation from GlyGen (Q96ST3) 10 sites, 2 O-linked glycans (10 sites)
- Protein Refseq
- XP_006720529.1
- Function
- Acts as a transcriptional repressor.
Corepressor for REST.
Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities.
Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA.
Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
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- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "SIN3A"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3265 | Hi-Affi™ Recombinant Rabbit Anti-SIN3A Monoclonal Antibody (DS3265AB) | WB, IHC, ICC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1032-CN | Recombinant Rabbit Anti-SIN3A Monoclonal Antibody (JA94-31) | WB, IF, IHC, FC | Rabbit IgG |
| ZG-0560U | Rabbit Anti-SIN3A Recombinant Antibody (clone 10G3) | ELISA, WB, IHC, IF | Rabbit IgG |
| VS3-WK270 | Rabbit Anti-SIN3A Recombinant Antibody (clone JA94-31) | WB, ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6597 | Anti-SIN3A Immunohistochemistry Kit | IHC |
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