Human Anti-SLC1A5 Recombinant Antibody Hexamer (VS-0924-YC150), CDC Enhanced
CAT#: VS-0924-YC150
The product is a human anti-SLC1A5 antibody hexamer with enhanced complement-dependent cytotoxicity (CDC) activity. This hexameric IgG1 targets both human and cynomolgus SLC1A5 and includes mutations that enhance hexamerization. These hexamerization-enhancing mutations promote optimal C1q binding, thereby boosting CDC activity.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35239/373_G10_1_selected.jpg
Normal Tissue
Figure 2 Salivary gland
High expression in salivary gland
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35240/70074_B_3_1_val_selected.jpg
Normal Tissue
Figure 3 Epididymis
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35240/70074_A_2_6.jpg
Normal Tissue
Figure 4 Lymph node
Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35240/70074_A_9_8.jpg
Normal Tissue
Figure 5 Colon
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35240/70074_A_7_3.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Collecting ducts Staining: Low Intensity: Moderate Quantity: <25% Distal tubules Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35240/70074_A_9_5.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000105281-SLC1A5
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Specifications
- Immunogen
- Human ASCT2
- Host Species
- Human
- Derivation
- Humanized
- Type
- Antibody hexamer
- Specificity
- Human and Cynomolgus SLC1A5
- Species Reactivity
- Human, Cynomolgus
- Molecule Class
- ~ 900 kDa
- Applications
- Cyt, FC, CDC
- Conjugate
- None
- Related Disease
- Cancer
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95% determined as SDS-PAGE and SEC-HPLC
- Aggregation
- <5%
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term (1-2 weeks). Store at -20°C long term (12 months). Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Solute Carrier Family 1 Member 5; Solute Carrier Family 1 (Neutral Amino Acid Transporter), Member 5; Sodium-Dependent Neutral Amino Acid Transporter Type 2; RD114/Simian Type D Retrovirus Receptor; Baboon M7 Virus Receptor; ATB(0); ASCT2; M7V1; RDRC
- Gene ID
- 6510
- UniProt ID
- Q15758
- Long Name
- Solute Carrier Family 1 Member 5
- Sequence Similarities
- Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A5 subfamily.
- Cellular Localization
- Cell membrane; Multi-pass membrane protein
Melanosome
- Post Translation Modifications
- Glycosylation at Asn212 and Asn163 ( NX_Q15758 [NX_Q15758-1] )
Ubiquitination at Lys372, Lys502, Lys522, and Lys537 ( NX_Q15758 [NX_Q15758-1] )
- Function
- Sodium-coupled antiporter of neutral amino acids.
(Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114. AAAT_HUMAN,Q15758
(Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus. AAAT_HUMAN,Q15758
(Microbial infection) Acts as a cell surface receptor for type D simian retroviruses. AAAT_HUMAN,Q15758
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COA
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| TAB-1009CLV | Anti-Human SLC1A5 Recombinant Antibody (TAB-1009CLV) | FC, ADCC, CDC, Inhib | Chimeric antibody (mouse/human) |
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| CAT | Product Name | Application | Type |
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| HPAB-N0245-YC | Human Anti-SLC1A5 Recombinant Antibody (HPAB-N0245-YC) | Cyt, FC, FuncS | Humanized IgG |
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| CAT | Product Name | Application | Type |
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| HPAB-N0245-YC-S(P) | Human Anti-SLC1A5 Recombinant Antibody; scFv Fragment (HPAB-N0245-YC-S(P)) | Cyt, FC, FuncS | Humanized scFv |
| CAT | Product Name | Application | Type |
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| HPAB-N0245-YC-F(E) | Human Anti-SLC1A5 Recombinant Antibody; Fab Fragment (HPAB-N0245-YC-F(E)) | Cyt, FC, FuncS | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| VS-0325-XY2087 | Anti-SLC1A5 Immunohistochemistry Kit | IHC | |
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