Mouse Anti-SLC40A1 Recombinant Antibody (VS-0624-FY65)
CAT#: VS-0624-FY65
This is a mouse monoclonal antibody that was developed to bind to the monkey homologue of Fpn. The clone 11F9 binds to HsFpn with nanomolar affinity and inhibits ion transport. The antibody inhibits TsFpn activity, and it also inhibits Co²⁺ and Fe²⁺ transport by HsFpn. The clone 45D8 exhibits a binding affinity that does not adhere to a linear epitope. Its application extends to both IF and FC assays.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/65634/1249_G12_3_selected.jpg
Normal Tissue
Figure 2 IHC staining of human liver
Immunohistochemical staining of human liver shows strong positivity in liver sinusoids.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/65634/155954_A_9_4_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/65634/155954_B_7_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/65634/155954_A_8_3.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (ASC diff, CACO-2, HEL, HMC-1, T-47d)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000138449-SLC40A1
❮
❯
| Sub Cat | Clone | Species Reactivity | Applications | Size | Conjugation | Endotoxin | Purity | Fc Engineering | |
| VS-0624-FY34 | 11F9 | Human, Monkey | Inhib | ||||||
| VS-0624-FY35 | 45D8 | Human | IF, FC |
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human and monkey SLC40A1
- Related Disease
- Hemochromatosis, Type 4 and Hemochromatosis, Type 1
Product Property
- Clonality
- Monoclonal Antibody
- Purification
- Protein G purified
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Ferroportin; FPN
- Gene ID
- 30061
- UniProt ID
- Q9NP59
- Long Name
- Ferroportin
- Sequence Similarities
- SLC40A subfamily
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Polyubiquitinated by RNF217; leading to proteasomal degradation.
Ubiquitination is necessary for its internalization by hepcidin/HAMP (PubMed:22682227).
(Q9NP59-S40A1_HUMAN)
Glycosylation at Asn434 (NX_Q9NP59 [NX_Q9NP59-1])
Modification sites at PhosphoSitePlus (Q9NP59)
Glycosylation from GlyGen (Q9NP59) 2 sites, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_047300022.1; XP_054197586.1; NP_055400.1
- Function
- Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "SLC40A1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-576CL | Human Anti-SLC40A1 Recombinant Antibody (TAB-576CL) | ELISA | Human IgG4 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-044WM | Mouse Anti-SLC40A1 Recombinant Antibody (TAB-044WM) | IF, WB, ELISA, IHC | Mouse IgG |
| TAB-044WM-S(P) | Mouse Anti-SLC40A1 Recombinant Antibody; scFv Fragment (TAB-044WM-S(P)) | ELISA, IHC, WB | Mouse scFv |
| TAB-044WM-F(E) | Mouse Anti-SLC40A1 Recombinant Antibody; Fab Fragment (TAB-044WM-F(E)) | ELISA, IHC, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-045WM | Human Anti-SLC40A1 Recombinant Antibody (TAB-045WM) | ELISA, WB | Human IgG |
| TAB-045WM-S(P) | Human Anti-SLC40A1 Recombinant Antibody; scFv Fragment (TAB-045WM-S(P)) | ELISA, WB | Human scFv |
| TAB-045WM-F(E) | Human Anti-SLC40A1 Recombinant Antibody; Fab Fragment (TAB-045WM-F(E)) | ELISA, WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0750-CN | Mouse Anti-SLC40A1 Recombinant Antibody (clone 34A9) | ELISA | Mouse IgG |
| HPAB-0752-CN | Human Anti-SLC40A1 Recombinant Antibody (clone 4A10-3) | ELISA | Humanized IgG4 |
| HPAB-0753-CN | Human Anti-SLC40A1 Recombinant Antibody (clone L2.2-4) | ELISA | Humanized IgG4 |
| HPAB-0754-CN | Human Anti-SLC40A1 Recombinant Antibody (clone Com11GY) | ELISA | Humanized IgG4 |
| HPAB-AP801-YC | Human Anti-SLC40A1 Recombinant Antibody (clone 3D8) | Inhib | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0750-CN-S(P) | Mouse Anti-SLC40A1 Recombinant Antibody (clone 34A9); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0752-CN-S(P) | Human Anti-SLC40A1 Recombinant Antibody (clone 4A10-3); scFv Fragment | ELISA | Humanized scFv |
| HPAB-0753-CN-S(P) | Human Anti-SLC40A1 Recombinant Antibody (clone L2.2-4); scFv Fragment | ELISA | Humanized scFv |
| HPAB-AP801-YC-S(P) | Human Anti-SLC40A1 Recombinant Antibody (clone 3D8); scFv Fragment | Inhib | Human scFv |
| HPAB-AP802-YC-S(P) | Human Anti-SLC40A1 Recombinant Antibody; scFv Fragment (HPAB-AP802-YC-S(P)) | ELISA, Inhib, FuncS | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0750-CN-F(E) | Mouse Anti-SLC40A1 Recombinant Antibody (clone 34A9); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0752-CN-F(E) | Human Anti-SLC40A1 Recombinant Antibody (clone 4A10-3); Fab Fragment | ELISA | Humanized Fab |
| HPAB-0753-CN-F(E) | Human Anti-SLC40A1 Recombinant Antibody (clone L2.2-4); Fab Fragment | ELISA | Humanized Fab |
| HPAB-0754-CN-F(E) | Human Anti-SLC40A1 Recombinant Antibody (clone Com11GY); Fab Fragment | ELISA | Humanized Fab |
| HPAB-AP801-YC-F(E) | Human Anti-SLC40A1 Recombinant Antibody (clone 3D8); Fab Fragment | Inhib | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC335 | Recombinant Anti-SLC40A1 Vesicular Antibody, EV Displayed (VS-0425-YC335) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6683 | Anti-SLC40A1 Immunohistochemistry Kit | IHC |
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