Mouse Anti-SOCS3 Recombinant Antibody (clone 5E12E7F1) (CAT#: VS7-0425-WR903)
This product is a mouse IgG1 antibody that binds to human SOCS3. The antibody 5E12E7F1 recognizes specific amino acid domain of human SOCS3 (AA: 1-225). It can be used for IHC, ICC, and FC assays.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68569/1358_H11_4_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/68569/1358_H11_4_selected.jpg
Figure 2 IHC staining of human gall bladder
(Immunohistochemical staining of human gall bladder shows distinct cytoplasmic and membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12220/ihc_selected.jpg
(Immunohistochemical staining of human gall bladder shows distinct cytoplasmic and membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12220/ihc_selected.jpg
Figure 3 Cerebral cortex
(Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12220/33045_B_9_5.jpg
(Neuronal cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12220/33045_B_9_5.jpg
Figure 4 Colon
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12220/33045_A_7_3.jpg
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12220/33045_A_7_3.jpg
Figure 5 Liver
(Cholangiocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12220/33045_A_8_4.jpg
(Cholangiocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12220/33045_A_8_4.jpg
Figure 6 Kidney
(Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12220/33045_A_7_5.jpg
(Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12220/33045_A_7_5.jpg
Figure 7 Testis
(Leydig cells Staining: Low Intensity: Weak Quantity:>75% Peritubular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Spermatogonia cells Staining: Low Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12220/33045_A_6_6.jpg
(Leydig cells Staining: Low Intensity: Weak Quantity:>75% Peritubular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Spermatogonia cells Staining: Low Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12220/33045_A_6_6.jpg
Figure 8 RNA cell line category: Cell line enhanced (HDLM-2, HSkMC, U-266/70)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000184557-SOCS3
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000184557-SOCS3
Specifications
- Immunogen
- Recombinant human SOCS3 (AA: 1-225) fragment expressed in E. Coli.
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human SOCS3
- Species Reactivity
- Human
- Clone
- 5E12E7F1
- Molecule Class
- Suppressor Of Cytokine Signaling (Socs) Family
- Applications
- IHC, ICC, FC
- Conjugate
- Unconjugated
- Related Disease
- There is some evidence that SOCS3 may be a susceptibility gene for atopic dermatitis linked to 17q25. SOCS3 messenger RNA is significantly more highly expressed in skin from patients with atopic dermatitis than in skin from healthy controls. Furthermore, a genetic association between atopic dermatitis and a haplotype in the SOCS3 gene has been found in two independent groups of patients
Product Property
- Clonality
- Monoclonal
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- 0.05% sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:500 - 1:2000
Immunohistochemistry-Paraffin: 1:200 - 1:1000
Immunocytochemistry: 1:200 - 1:1000
Flow Cytometry: 1:200 - 1:400
Enzyme-linked Immunosorbent Assay: 1:10000
Target
- Alternative Names
- SOCS3; SSI3; CIS3; ATOD4; CIS-3; STAT-Induced STAT Inhibitor 3; Suppressor Of Cytokine Signaling 3; Cish3; SSI-3; SOCS-3; Cytokine-Inducible SH2 Protein 3
- Gene ID
- 9021
- UniProt ID
- O14543
- Long Name
- Suppressor of cytokine signaling 3
- Cellular Localization
- cytoplasmic side of plasma membrane; cytosol
- Post Translation Modifications
- Phosphoprotein
- Protein Refseq
- NP_001365861.1
- Function
- Signal transduction inhibitor
Recommended Products
Isotype Control
Secondary Antibody
Reconstitution Buffer
Recommended Dilution Buffer
Related Resources
TNF Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3573z | Mouse Anti-SOCS3 Recombinant Antibody (clone 32G3) | WB, IP, ELISA | Mouse IgG2b, κ |
| MOB-1968MZ | Recombinant Mouse Anti-Human SOCS3 Antibody (clone TP2) | ELISA, IHC-P, WB | Mouse antibody |
| VS3-CJ6 | Mouse Anti-SOCS3 Recombinant Antibody (VS3-CJ6) | WB, ELISA | Mouse IgG |
| VS7-0425-WR902 | Mouse Anti-SOCS3 Recombinant Antibody (clone 3A10A12) | WB, IHC, ICC, FC | Mouse IgG1 |
| VS7-0425-WR904 | Mouse Anti-SOCS3 Recombinant Antibody (VS7-0425-WR904) | WB, IHC-P, IF | Mouse IgG |
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