Rabbit Anti-SOX2 Recombinant Antibody (VS13-YC1098) (CAT#: VS13-YC1098)
The Rabbit Anti-SOX2 Recombinant Antibody is specific for human SOX2. SOX2, an intronless gene, encodes a transcription factor vital for CNS stem cell maintenance and stomach gene expression, associated with optic nerve hypoplasia and syndromic microphthalmia. The anti-SOX2 antibody can be used for Immunohistochemistry-paraffin (1/1000).
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/45725/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/45725/if_selected.jpg
Figure 2 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/62851/1273_B4_7_selected.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/62851/1273_B4_7_selected.jpg
Figure 3 High expression in cerebral cortex
(Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/79745/167827_B_9_5.jpg
(Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/79745/167827_B_9_5.jpg
Figure 4 Esophagus
(Squamous epithelial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/79745/167827_B_6_1.jpg
(Squamous epithelial cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/79745/167827_B_6_1.jpg
Figure 5 Colon
(Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/79745/167827_A_7_3.jpg
(Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/79745/167827_A_7_3.jpg
Figure 6 RNA cell line category: Cell line enhanced (AF22, HAP1, NTERA-2, U-251 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000181449-SOX2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000181449-SOX2
Specifications
- Immunogen
- Recombinant human SOX2, aa 1-100.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human SOX2
- Species Reactivity
- Human
- Applications
- IHC-P
- Conjugate
- NONE
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS (pH 7.4) containing 40% Glycerol and 0.1% BSA.
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Immunohistochemistry-paraffin (IHC-P): 1/1000
Target
- Alternative Names
- SRY-Box 2; SRY (Sex Determining Region Y)-Box 2; Sex Determining Region Y-Box 2; SRY-Related HMG-Box Gene 2; Transcription Factor SOX-2; Transcription Factor SOX2; SRY Box 2; MCOPS3; ANOP3;
- Gene ID
- 6657
- UniProt ID
- P48431
- Long Name
- SRY-Box 2
- Cellular Localization
- Nucleus
- Protein Refseq
- NP_003097.1
- Function
- Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity).
Binds to the proximal enhancer region of NANOG (By similarity).
Critical for early embryogenesis and for embryonic stem cell pluripotency (PubMed:18035408).
Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity).
Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).
May function as a switch in neuronal development (By similarity).
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1906CT | Recombinant Mouse anti-Human SOX2 Monoclonal antibody (68DU34.4.5) | ELISA, ICC/IF, IHC-P, WB, sELISA | |
| ZG-0015U | Rabbit Anti-SOX2 Recombinant Antibody (clone 2E1) | ELISA, WB, IHC | Rabbit IgG |
| VS3-QX1042 | Mouse Anti-SOX2 Recombinant Antibody (clone 2A10-F11-F12) | WB, FC, ICC | Mouse IgG1 |
| VS3-QX1043 | Mouse Anti-SOX2 Recombinant Antibody (clone 57CT23.3.4) | WB, ICC, IHC, FC | Mouse IgG1 |
| VS3-QX1044 | Mouse Anti-SOX2 Recombinant Antibody (clone 10F10C9) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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