Human Anti-TFRC Recombinant Antibody (clone TSP-A02)

Name: Human Anti-TFRC Recombinant Antibody (clone TSP-A02)
SKU: VS-0724-XY89
Rating: 5 (1 reviews)

CAT#: VS-0724-XY89

This product is a recombinant human antibody specifically recognizes human TFRC (Transferrin receptor), which is a cell surface receptor necessary for cellular iron uptake. This antibody has been determined using ELISA, Flow cytometry and Neutralizaiton assay.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to endosomes & lysosomes.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/28598/546_F8_1_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/207_B2_1_blue_red_green.jpg

Subcellular Location Figure 3 IF staining of human cell line U-2 OS

Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/208_B2_1_blue_red_green.jpg

Normal Tissue Figure 4 Cerebral cortex

Endothelial cells
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_B_9_5.jpg

Normal Tissue Figure 5 Colon

Glandular cells
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_A_8_3.jpg

Normal Tissue Figure 6 Testis

Leydig cells
Staining:

Medium

Intensity: Strong
Quantity: <25%
Pachytene spermatocytes
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_A_6_6.jpg

Normal Tissue Figure 7 Bone marrow

Hematopoietic cells
Staining:

High

Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_B_6_4.jpg

Normal Tissue Figure 8 Lymph node

Germinal center cells
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_A_8_8.jpg

RNA Expression Figure 9 RNA cell line category: Cell line enhanced (HDLM-2)

Cell lines ordered by descending RNA expression order.

RNA Expression Figure 9 RNA cell line category: Cell line enhanced (HDLM-2)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000072274-TFRC

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Specifications

Host Species
Human

Type
Human IgG

Specificity
TFRC

Species Reactivity
Human

Clone
TSP-A02

Applications
ELISA, FC, Neut

Related Disease
Immunodeficiency 46; Combined Immunodeficiency

Product Property

Purification
Protein A affinity purified

Purity
>95%, determined by SDS-PAGE

Format
Liquid

Buffer
PBS

Preservative
No preservatives

Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target

Alternative Names
T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46

Gene ID
7037

UniProt ID
P02786

Cellular Localization
Cell membrane

Post Translation Modifications
Glycosylation at Asn50, Asn55, Thr104, Asn251, Asn317, and Asn727.
Ubiquitination at Lys39, Lys224, Lys344, Lys358, and Lys720.

Protein Refseq
XP_047304742.1; XP_054203635.1; XP_054203636.1

Function
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (PubMed:26214738).
Endosomal acidification leads to iron release.
The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor.

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Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - VS-0724-XY89.pdf

MSDS

MSDS - VS-0724-XY89.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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