1 0
Cart
    Inquiry
    Popular Searches: Recombinant Antibody MHC Tetramer T cell Receptor Scaffold Protein

    Anti-TFRC immunotoxin HB21 (scFv)-RTA (CAT#: AGTO-G067R)

    This immunotoxin was achieved by conjugating/fusing the Anti-TFRC scFv to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of malignant.

    Specific Inquiry
    • Size:

    • Conjugation:

    • Endotoxin:

    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
    Endotoxin :
    Quantity :
    Conjugation :
    Fc Engineering :
    Modalities :
    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line U-251 MG
    Figure 1 IF staining of human cell line U-251 MG
    (Immunofluorescent staining of human cell line U-251 MG shows localization to endosomes & lysosomes.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/28598/546_F8_1_selected.jpg
    Figure 2 IF staining of human cell line A-431
    Figure 2 IF staining of human cell line A-431
    (Immunofluorescent staining of human cell line A-431 shows localization to vesicles.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/207_B2_1_blue_red_green.jpg
    Figure 3 IF staining of human cell line U-2 OS
    Figure 3 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/208_B2_1_blue_red_green.jpg
    Normal Tissue
    Figure 4 Cerebral cortex
    Figure 4 Cerebral cortex
    (Endothelial cells
    Staining:

    Medium

    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_B_9_5.jpg
    Figure 5 Colon
    Figure 5 Colon
    (Glandular cells
    Staining:

    Medium

    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_A_8_3.jpg
    Figure 6 Testis
    Figure 6 Testis
    (Leydig cells
    Staining:

    Medium

    Intensity: Strong
    Quantity: <25%
    Pachytene spermatocytes
    Staining:

    Medium

    Intensity: Moderate
    Quantity: 75%-25%)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_A_6_6.jpg
    Figure 7 Bone marrow
    Figure 7 Bone marrow
    (Hematopoietic cells
    Staining:

    High

    Intensity: Strong
    Quantity: 75%-25%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_B_6_4.jpg
    Figure 8 Lymph node
    Figure 8 Lymph node
    (Germinal center cells
    Staining:

    Medium

    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_A_8_8.jpg
    RNA Expression
    Figure 9 RNA cell line category: Cell line enhanced (HDLM-2)
    Figure 9 RNA cell line category: Cell line enhanced (HDLM-2)
    (Cell lines ordered by descending RNA expression order.)
    * https://v21.proteinatlas.org/ENSG00000072274-TFRC
    Figure 9 RNA cell line category: Cell line enhanced (HDLM-2)
    Figure 9 RNA cell line category: Cell line enhanced (HDLM-2)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000072274-TFRC

    Specifications

    • Host Species
    • Mouse
    • Species Reactivity
    • Human
    • Clone
    • HB21
    • Molecule Class
    • scFv-RTA
    • Toxin Description
    • Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
    • Applications
    • This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
    • Related Disease
    • malignant

    Target

    • Alternative Names
    • TFRC; transferrin receptor; T9; TR; TFR; p90; CD71; TFR1; TRFR; transferrin receptor protein 1; transferrin receptor (p90, CD71); Deglycosylated ricin A chain; Ricin A chain; Ricin A; Ricin; RTA; RT; RA; dgRTA; dgRA; dgA

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "Clone HB21"

    See other products for "TFRC"

    Select a product category from the dropdown menu below to view related products.
    Please select product type
    Immunotoxin Products Human Antibody Products Humanized Antibody Products IgM Antibody Products Mouse Antibody Products Blocking Antibody Products Rabbit Monoclonal Antibody Products MHC Tetramer Products for Cancer IgG Antibody Products ScFv Antibody Products Fab Antibody Products Antibody Magnetic Beads Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research Extracellular Vesicle (EV) Antibody Products
    CAT Product Name Application Type
    AGTO-G067E Anti-TFRC immunotoxin HB21 (scFv)-PE Cytotoxicity assay, Function study
    AGTO-G067D Anti-TFRC immunotoxin HB21 (scFv)-DT Cytotoxicity assay, Function study
    AGTO-G067G Anti-TFRC immunotoxin HB21 (scFv)-Gel Cytotoxicity assay, Function study
    AGTO-L076E transferrin-PE immunotoxin Cytotoxicity assay, Functional assay
    AGTO-L076R transferrin-RTA immunotoxin Cytotoxicity assay, Functional assay

    Customer Reviews and Q&As

    Submit a review or a question

    There are currently no Customer reviews or questions for AGTO-G067R. Click the button above to contact us or submit your feedback about this product.

    Popular products with customers

    Figure 1 Anti-P. aeruginosa psl Antibody in SDS-PAGE

    Recombinant Anti-P. aeruginosa psl Antibody (CAT# MOB-736)
    Application: WB, IP, FuncS

    Figure 5 Anti-Human ErbB2 Recombinant Antibody (Trastuzumab) (TAB-005) in SDS-PAGE

    Anti-Human ErbB2 Recombinant Antibody (TAB-005) (CAT# TAB-005)
    Application: FC, IP, ELISA, Neut, FuncS, IF, IHC

    Figure 3 Anti-CD40 Antibody (TAB-039) in Dot Blot

    Anti-Human CD4 Recombinant Antibody (Zanolimumab) (CAT# TAB-039)
    Application: Neut, ELISA, IF, IP, FuncS, FC, IHC

    Figure 1 Anti-Human Integrin alpha 5 beta 1 Recombinant Antibody in SDS-PAGE analysis.

    Anti-Human Integrin alpha 5 beta 1 Recombinant Antibody (Volociximab) (CAT# TAB-077)
    Application: ELISA, IHC

    Figure 2 Human CD27 Recombinant Antibody (TAB-H74) in HPLC

    Human Anti-Human CD27 Recombinant Antibody (TAB-H74) (CAT# TAB-H74)
    Application: ELISA, IP, FC, FuncS, Neut, IF, ICC

    Figure 1 Recombinant Human Anti-GM3 Antibody (MHH-407) in SDS-PAGE

    Recombinant Human Anti-GM3 Antibody (CAT# MHH-407)
    Application: IP, IF, Biosensors, FuncS

    Figure 3 Llama Anti-human IgG-CH1 VHH Single Domain Antibody (VHH-His-Cys) (NABG-112-UN) in DB

    Llama Anti-human IgG-CH1 VHH Single Domain Antibody [Biotin] (CAT# NABG-112)
    Application: ELISA, WB, BLI, SPR

    Figure 3 Anti-Human CTGF Recombinant Antibody (TAB-194CL) in ELISA.

    Anti-Human CTGF Recombinant Antibody (TAB-194CL) (CAT# TAB-194CL)
    Application: WB, IHC, IF

    Figure 1 Human IgG4 Isotype Control Antibody (MOB-0408ZL) in SDS-PAGE

    Human IgG4 Isotype Control Antibody (CAT# MOB-0408ZL)
    Application: ELISA, IB, FC, IHC, FuncS

    Figure 2 Anti-Human EGFR Antibody (PABW-088) in DB

    Mouse Anti-EGFR Recombinant Antibody (clone 7A7) (CAT# PABW-088)
    Application: ELISA, WB

    Figure 2 Human Anti-VEGF Recombinant Antibody (PABC-131) in ELISA

    Human Anti-VEGF Recombinant Antibody (clone B20-4) (CAT# PABC-131)
    Application: ELISA, Neut, Block

    Figure 2 Anti-Human CD19 Recombinant Antibody Fab Fragment [TAB-1611CL-F(E)] in HPLC

    Mouse Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1611CL-F(E)) (CAT# TAB-1611CL-F(E))
    Application: Depletion, FuncS

    Figure 3 Anti-Human IgE Recombinant Antibody Fab Fragment (CMAB007) in ELISA.

    Anti-Human IgE Recombinant Antibody Fab Fragment (CMAB007) (CAT# TAB-034ZJ-F(E))
    Application: ELISA

    Figure 1 Anti-Human TfR Recombinant Antibody (TAB-628CT) in SDS-PAGE

    Anti-Human TfR Recombinant Antibody (3GH7 ) (CAT# TAB-628CT)
    Application: WB

    Figure 5 Mouse Anti-HIV-1 p24 Recombinant Antibody (clone AG3.0) (MRO-961CQ) in SEC-HPLC.

    Mouse Anti-HIV-1 p24 Recombinant Antibody (clone AG3.0) (CAT# MRO-961CQ)
    Application: ELISA

    Figure 2 Human Anti-IL15 Recombinant Antibody (HPAB-0238-YC) in WB

    Human Anti-IL15 Recombinant Antibody (HPAB-0238-YC) (CAT# HPAB-0238-YC)
    Application: ELISA, FC, Inhib, FuncS

    Figure 2 Mouse Anti-GDF15 Recombinant Antibody (HPAB-0344-CN) in HPLC

    Mouse Anti-GDF15 Recombinant Antibody (HPAB-0344-CN) (CAT# HPAB-0344-CN)
    Application: WB, FC, Block

    Figure 4 Anti-SIRPA Recombinant Antibody (NS-080CN) in ELISA

    Human Anti-SIRPA Recombinant Antibody (clone 29-AM3-35) (CAT# NS-080CN)
    Application: ELISA, Inhib, FuncS

    Figure 2 Human Anti-HLA-DR4 Recombinant Antibody (HPAB-0826-FY) in HPLC

    Human Anti-HLA-DR4/GAD-555-567 Recombinant Antibody (clone G3H8) (CAT# HPAB-0826-FY)
    Application: FC

    Figure 4 Mouse Anti-ACTA2 Antibody (ZG-1036F) in IHC

    Mouse Anti-ACTA2 Recombinant Antibody (clone HHF35) (CAT# ZG-1036F)
    Application: EM, ELISA, ICC, IHC-Fr, IHC-P, WB

    For Research Use Only. Not For Clinical Use.

    For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

    Send Inquiry

    This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

    Go to compare

    Go to compare