Anti-TFRC immunotoxin HB21 (scFv)-RTA
CAT#: AGTO-G067R
This immunotoxin was achieved by conjugating/fusing the Anti-TFRC scFv to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of malignant.










Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Clone
- HB21
- Molecule Class
- scFv-RTA
- Toxin Description
- Ricin consist of two polypeptide chains, A and B, linked by means of disulfide bridge(s). Cytotoxicity is associated with the A chain and its 15 inhibition of protein synthesis in nucleated cells. The B chain is essentially a delivery vehicle for the A chain. The B chain recognizes polysaccharide units at the surface of cells and creates a high affinity interaction with such units. Once the B chain binds with polysaccharide units at 20" the celL surface, the A chain is incorporated into the cell, blocking ribosomal protein synthesis and ultimately leading tocell death. The use of ricin A chain is preferred in this invention.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- malignant
Target
Customer Review
There are currently no Customer reviews or questions for AGTO-G067R. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
See other products for "Clone HB21"
- CAT
- Product Name
See other products for "TFRC"
Select a product category from the dropdown menu below to view related products.
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1176z-S(P) | Recombinant Anti-Human TFRC Antibody scFv Fragment | ELISA, WB, IF, FuncS | scFv |
HPAB-2700LY-S(P) | Mouse Anti-TFRC Recombinant Antibody; scFv Fragment (HPAB-2700LY-S(P)) | ELISA | Mouse scFv |
HPAB-2701LY-S(P) | Mouse Anti-TFRC Recombinant Antibody; scFv Fragment (HPAB-2701LY-S(P)) | ELISA | Mouse scFv |
HPAB-2702LY-S(P) | Mouse Anti-TFRC Recombinant Antibody; scFv Fragment (HPAB-2702LY-S(P)) | ELISA | Mouse scFv |
HPAB-2703LY-S(P) | Mouse Anti-TFRC Recombinant Antibody; scFv Fragment (HPAB-2703LY-S(P)) | ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-G067E | Anti-TFRC immunotoxin HB21 (scFv)-PE | Cytotoxicity assay, Function study | |
AGTO-G067D | Anti-TFRC immunotoxin HB21 (scFv)-DT | Cytotoxicity assay, Function study | |
AGTO-G067G | Anti-TFRC immunotoxin HB21 (scFv)-Gel | Cytotoxicity assay, Function study | |
AGTO-G067S | Anti-TFRC immunotoxin HB21 (scFv)-Sap | Cytotoxicity assay, Function study | |
AGTO-G068E | Anti-TFRC immunotoxin 454A12 (IgG)-PE | Cytotoxicity assay, Function study |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0464CL-S(P) | Mouse Anti-TFRC Recombinant Antibody; scFv Fragment (TAB-0464CL-S(P)) | FuncS | Mouse scFv |
TAB-0465CL-S(P) | Mouse Anti-TFRC Recombinant Antibody; scFv Fragment (TAB-0465CL-S(P)) | FuncS | Mouse scFv |
TAB-616CT | Anti-Human TfR Recombinant Antibody (55-31) | ELISA, WB, IP | |
TAB-617CT | Anti-Human TfR Recombinant Antibody (122-72) | ELISA, WB, IP | |
TAB-618CT | Anti-Human TfR Recombinant Antibody (5D7-54.17) | ELISA, WB, IP |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0467CL-S(P) | Human Anti-TFRC Recombinant Antibody; scFv Fragment (TAB-0467CL-S(P)) | FuncS | Human scFv |
TAB-619CT-S(P) | Human Anti-TFRC Recombinant Antibody; scFv Fragment (TAB-619CT-S(P)) | ELISA, WB | Human scFv |
TAB-620CT-S(P) | Human Anti-TFRC Recombinant Antibody; scFv Fragment (TAB-620CT-S(P)) | ELISA, WB | Human scFv |
TAB-621CT-S(P) | Anti-Human TfR Recombinant Antibody scFv Fragment (LUCA31) | ELISA, WB, FC | Human antibody |
TAB-623CT-S(P) | Anti-Human TfR Recombinant Antibody scFv Fragment (3TF12) | WB | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-611CT | Humanized Anti-TFRC Recombinant Antibody (TAB-611CT) | ELISA | Humanized IgG |
TAB-612CT | Humanized Anti-TFRC Recombinant Antibody (TAB-612CT) | ELISA | Humanized IgG |
TAB-613CT | Humanized Anti-TFRC Recombinant Antibody (TAB-613CT) | ELISA | Humanized IgG |
TAB-614CT | Humanized Anti-TFRC Recombinant Antibody (TAB-614CT) | ELISA | Humanized IgG |
TAB-611CT-S(P) | Humanized Anti-TFRC Recombinant Antibody; scFv Fragment (TAB-611CT-S(P)) | ELISA | Humanized scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-615CT | Anti-Human TfR Recombinant Antibody (6-90) | ELISA, WB, IP |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-1999CQ | Rat Anti-Tfrc Recombinant Antibody (clone RI7217) | FC, ICC, IP, WB, Block | Rat IgG2a, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-3548 | Rabbit Anti-TFRC Recombinant Antibody (clone DS3548AB) | FC, IP, WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MHC-LC3370 | PE-DRB1*13:02/Human TFRC (NPGGYVAYSKAATVTGKL) MHC Tetramer | FCM | |
MHC-LC3371 | PE-DRB1*13:02/Human TFRC (NPGGYVAYSKAATVTG) MHC Tetramer | FCM |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0376-CN | Mouse Anti-TFRC Recombinant Antibody (HPAB-0376-CN) | ELISA, FC | Mouse IgG |
HPAB-0377-CN | Mouse Anti-TFRC Recombinant Antibody (HPAB-0377-CN) | ELISA, FC | Mouse IgG |
HPAB-0378-CN | Mouse Anti-TFRC Recombinant Antibody (HPAB-0378-CN) | ELISA, FC | Mouse IgG |
HPAB-0379-CN | Human Anti-TFRC Recombinant Antibody (HPAB-0379-CN) | ELISA, FC | Humanized IgG |
HPAB-0380-CN | Mouse Anti-TFRC Recombinant Antibody (HPAB-0380-CN) | ELISA, FC, IF, IP | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0376-CN-F(E) | Mouse Anti-TFRC Recombinant Antibody; Fab Fragment (HPAB-0376-CN-F(E)) | ELISA, FC | Mouse Fab |
HPAB-0377-CN-F(E) | Mouse Anti-TFRC Recombinant Antibody; Fab Fragment (HPAB-0377-CN-F(E)) | ELISA, FC | Mouse Fab |
HPAB-0378-CN-F(E) | Mouse Anti-TFRC Recombinant Antibody; Fab Fragment (HPAB-0378-CN-F(E)) | ELISA, FC | Mouse Fab |
HPAB-0379-CN-F(E) | Human Anti-TFRC Recombinant Antibody; Fab Fragment (HPAB-0379-CN-F(E)) | ELISA, FC | Humanized Fab |
HPAB-0380-CN-F(E) | Mouse Anti-TFRC Recombinant Antibody Fab Fragment (HPAB-0380-CN-F(E)) | ELISA, FC, IF, IP | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0724-YC1481 | AbPlus™ Anti-TFRC Magnetic Beads (VS-0724-YC1481) | IP, Protein Purification |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0225-XY205 | CytoStream™ Mouse Anti-TFRC Recombinant Antibody (clone OX-26) | FC, IHC, IP | Mouse IgG2a, kappa |
VS-0225-XY206 | CytoStream™ Rat Anti-TFRC Recombinant Antibody (clone RI7217) | FC | Rat IgG2a, kappa |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0425-YC571 | Recombinant Anti-TFRC Vesicular Antibody, EV Displayed (VS-0425-YC571) | ELISA, FC, Cell-uptake |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0525-XY7200 | Anti-Mouse TFRC Immunohistochemistry Kit | IHC | |
VS-0525-XY7201 | Anti-Rat TFRC Immunohistochemistry Kit | IHC |
Popular Products
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: ELISA, WB, BLI, SPR
Application: WB, ELISA
Application: ELISA, FuncS
Application: Neut
Application: Neut, ELISA, IF, IP, FuncS, FC
Application: ELISA, Cyt, PP, Inhib
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.