Creative Biolabs Recombinant Antibodies
Products
  1. Home
  2. TFRC
  3. Anti-TFRC immunotoxin HB21 (scFv)-DT

Anti-TFRC immunotoxin HB21 (scFv)-DT (AGTO-G067D)

This immunotoxin was achieved by conjugating/fusing the Anti-TFRC scFv to Diphtheria toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells and the toxin enters cells by receptor-mediated endocytosis. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death. It was designed for treatment of malignant.      
  • Datasheet

Specifications
Host
Mouse
Species Reactivity
Human
Clone
HB21
Molecule Class
scFv-DT
Toxin Description
Diphtheria toxin (Diphtheriatoxin, DT) is a cell toxin produced by diphtheria, is a protein toxin most commonly used in the construction of recombinant immunotoxin. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
malignant
Target
Alternative Names
TFRC; transferrin receptor; T9; TR; TFR; p90; CD71; TFR1
Entrez Gene ID
7037
UniProt ID
P02786

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

See other products for "TFRC"
Anti-TFRC immunotoxin 454A12 (IgG)-RTA    ( AGTO-G068R )
transferrin-RTA immunotoxin    ( AGTO-L076R )
Anti-TFRC immunotoxin 454A12 (IgG)-Gel    ( AGTO-G068G )
Anti-Human TfR Therapeutic Antibody Fab Fragment (15G11)    ( TAB-611CT-F(E) )
Anti-Human TfR Therapeutic Antibody scFv Fragment (122-72)    ( TAB-617CT-S(P) )
Recombinant Anti-Human TFRC Antibody Fab Fragment    ( MOB-1176z-F(E) )
Recombinant Mouse Anti-TFRC Antibody (OX26)    ( FAMAB-0281YC )
Anti-Human TfR Therapeutic Antibody (3TF12)    ( TAB-623CT )
>> MORE
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Send Inquiry Now!
Name:
* Phone:
* E-mail Address:
* Service & Products Interested:
Project Description:
* Verification Code:
Please input "biolabs"(case insensitive) as verification code.
Contact Us to Order
Tel: 1-631-381-2994
Fax: 1-631-207-8356
Email:

Increase Efficiency to Accelerate Your Research & Discovery Process

Increase Efficiency to Accelerate Your Research & Discovery Process

Creative Biolabs is the leading custom service provider that has extensive experience in various antibody production and engineering fields. Our service portfolio includes mouse and rat monoclonal antibody production ...

Find out more >

USA

45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-381-2994
Fax: 1-631-207-8356

Europe

Tel: 44-207-097-1828
Email:
Follow us on:
           

Terms of Service-Privacy Policy     © 2007 - 2019 Creative-Biolabs All Rights Reserved