Mouse Anti-TGFB2 Recombinant Antibody (VS3-CJ1082) (CAT#: VS3-CJ1082)
This product is a mouse antibody that recognizes human TGFB2.
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Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line EFO-21
(Immunofluorescent staining of human cell line EFO-21 shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6134/2063_C8_2_selected.jpg
(Immunofluorescent staining of human cell line EFO-21 shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6134/2063_C8_2_selected.jpg
Figure 2 RNA cell line category: Cell line enhanced (EFO-21, hTERT-RPE1, U-2 OS)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000092969-TGFB2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000092969-TGFB2
Specifications
- Immunogen
- Recombinant protein of TGFB2
- Host Species
- Mouse
- Type
- Mouse IgG1, κ
- Specificity
- Human TGFB2
- Species Reactivity
- Human
- Applications
- WB, ICC, IHC
- Conjugate
- Unconjugated
Product Property
- Purification
- Protein G affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- PBS
- Preservative
- 0.09% Sodium Azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Western Blot (1:500-1:1000), Immunocytochemistry (1:10-1:50), Immunohistochemistry (1:10-1:50).
Target
- Alternative Names
- LDS4; G-TSF; TGF-beta2
- Gene ID
- 7042
- UniProt ID
- P61812
- Sequence Similarities
- Belongs to the TGF-beta family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Transforming growth factor beta-2 proprotein:
The precursor proprotein is cleaved in the Golgi apparatus to form Transforming growth factor beta-2 (TGF-beta-2) and Latency-associated peptide (LAP) chains, which remain non-covalently linked, rendering TGF-beta-2 inactive.
- Protein Refseq
- NP_001129071.1; NP_003229.1
- Function
- Transforming growth factor beta-2 proprotein:
Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.
Latency-associated peptide:
Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix (By similarity).
Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 (By similarity).
Transforming growth factor beta-2:
Multifunctional protein that regulates various processes such as angiogenesis and heart development (PubMed:22772371, PubMed:22772368).
Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix (By similarity).
At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus (By similarity).
Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity).
Recommended Products
Secondary Antibody
Recommended Dilution Buffer
Related Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IHC Kits & Antibodies
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1494z-F(E) | Recombinant Anti-Human TGFB2 Antibody Fab Fragment | FC, Neut, Funcs | Fab |
| HPAB-M0662-YC-F(E) | Human Anti-TGFB2 Recombinant Antibody; Fab Fragment (HPAB-M0662-YC-F(E)) | ELISA, FuncS | Human Fab |
| HPAB-M0663-YC-F(E) | Human Anti-TGFB2 Recombinant Antibody; Fab Fragment (HPAB-M0663-YC-F(E)) | ELISA, FuncS | Human Fab |
| HPAB-M0664-YC-F(E) | Human Anti-TGFB2 Recombinant Antibody; Fab Fragment (HPAB-M0664-YC-F(E)) | ELISA, FuncS | Human Fab |
| HPAB-0665YY-F(E) | Human Anti-TGFB2 Recombinant Antibody (clone GDF11 Inh-2); Fab Fragment | Inhib, ELISA, WB | Human Fab |
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