Anti-TNC Antibody-Cytokine Fusion Protein, scfv (R6N)-mIL12 (CAT#: VS-0624-FY81)

R6N is a mouse antibody that binds to TNC-D. IL-12 plays an important role in the activity of natural killer cells and T lymphocytes. IL-12 mediates the enhancement of the cytotoxic activity of NK cells and CD8⁺ cytotoxic T lymphocytes. This product is a novel recombinant mIL12-R6N fusion protein with potent single-agent activity that inhibits tumor growth in treated mice. The fusion protein mIL12-R6N comprises the R6N antibody arranged in a homodimeric tandem scFv format fused to murine IL12 at the N-terminus.

Specific Inquiry
  • Size:

  • Conjugation:

  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression

Specifications

  • Target
  • TNC-D
  • Molecule Class
  • scfv-IL12
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Clone
  • R6N
  • Related Disease
  • Brain tumors
  • Cytokine 1
  • IL12
  • Cytokines 1 Description
  • Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, helper T cells, and human B lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 belongs to the interleukin 12 family. The IL-12 family is unique in that it contains only heterodimeric cytokines, including IL-12, IL-23, IL-27, and IL-35. Although they share many common structural features and molecular partners, the functional effects they mediate are surprisingly diverse.
  • Cytokine 1 Species
  • Mouse
  • Applications
  • This product is for immuno therapy research. It can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

  • Introduction
  • This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration.
  • Alternative Names
  • Tenascin C; Glioma-Associated-Extracellular Matrix Antigen; Deafness, Autosomal Dominant 56; Hexabrachion (Tenascin); Myotendinous Antigen; Neuronectin; GP 150-225; Cytotactin; GMEM; TN-C; HXB; TN; mIL12-R6N

Downloads

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CAT Product Name Application Type
TAB-877 Anti-Human Tenascin C/TNC Recombinant Antibody (Tenatumomab) IHC IgG2b

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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