Mouse Anti-UHRF1 Recombinant Antibody (clone 1A1B1)
CAT#: VS7-0425-WR1088
This product is a mouse IgG2b antibody that binds to human UHRF1. The antibody 1A1B1 recognizes specific amino acid domain of human UHRF1 (AA: 616-755). It can be used for WB, IHC, ICC, and FC assays.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49408/if_selected.jpg
Normal Tissue
Figure 2 Colon
Enterocytes -
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55446/165825_A_8_3.jpg
Normal Tissue
Figure 3 Testis
Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55446/165825_A_6_6.jpg
Normal Tissue
Figure 4 Lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55446/165825_A_7_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (MOLT-4, REH)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000276043-UHRF1
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Specifications
- Immunogen
- Recombinant human UHRF1 (AA: 616-755) fragment expressed in E. Coli.
- Host Species
- Mouse
- Type
- Mouse IgG2b
- Specificity
- Human UHRF1
- Species Reactivity
- Human
- Clone
- 1A1B1
- Molecule Class
- E3 Ubiquitin Ligase
- Applications
- WB, IHC, ICC, FC
- Conjugate
- Unconjugated
- Related Disease
- Defects in UHRF1 may be a cause of cancers. Overexpressed in many different forms of human cancers, including bladder, breast, cervical, colorectal and prostate cancers, as well as pancreatic adenocarcinomas, rhabdomyosarcomas and gliomas. Plays an important role in the correlation of histone modification and gene silencing in cancer progression. Expression is associated with a poor prognosis in patients with various cancers, suggesting that it participates in cancer progression
Product Property
- Clonality
- Monoclonal
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- 0.05% sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:500 - 1:2000
Immunohistochemistry-Paraffin: 1:200 - 1:1000
Immunocytochemistry: 1:200 - 1:1000
Flow Cytometry: 1:200 - 1:400
Enzyme-linked Immunosorbent Assay: 1:10000
Target
- Alternative Names
- Ubiquitin Like With PHD And Ring Finger Domains 1; Ubiquitin-Like PHD And RING Finger Domain-Containing Protein 1; Inverted CCAAT Box-Binding Protein Of 90 KDa; RING-Type E3 Ubiquitin Transferase UHRF1; Nuclear Zinc Finger Protein Np95; Transcription Factor ICBP90; RING Finger Protein 106; Nuclear Protein 95; HuNp95; ICBP90; RNF106
- Gene ID
- 29128
- UniProt ID
- Q96T88
- Long Name
- Ubiquitin Like With PHD And Ring Finger Domains 1
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Acetylation; Isopeptide bond; Phosphoprotein; Ubl conjugation
- Protein Refseq
- NP_001041666.1
- Function
- Chromatin regulator; DNA-binding; Repressor; Transferase
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
Reconstitution Buffer
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
See other products for "UHRF1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1229MZ | Recombinant Mouse Anti-Human UHRF1 Antibody | ICC, IF, IHC-P, WB | Mouse antibody |
| VS3-QX1219 | Mouse Anti-UHRF1 Recombinant Antibody (clone 1H9-D3-E11) | WB | Mouse IgG2b |
| VS3-CJ68 | Mouse Anti-UHRF1 Recombinant Antibody (VS3-CJ68) | WB, ELISA | Mouse IgG |
| VS4-CJ148 | Recombinant Mouse Anti-UHRF1 Antibody (VS4-CJ148) | ELISA, WB, ICC | Mouse IgG2b |
| VS7-0425-WR1087 | Mouse Anti-UHRF1 Recombinant Antibody (clone 2A8C7) | WB, IHC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2434 | Anti-UHRF1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7739 | Anti-Mouse UHRF1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7738 | Anti-Human UHRF1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7740 | Anti-Rat UHRF1 Immunohistochemistry Kit | IHC |
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