anti-HIgG(Fc)-C-PNU ADC (CAT#: ADC-1007-SHz)
This ADC product is composed of an anti-human IgG Fc specific polyclonal antibody conjugated via a cleavable linker to PNU-159682 (anti-human IgG(Fc)-CL-PNU). The antibody portion is a secondary antibody and the drug portion, PNU-159682, is a derivative of nemorubicin which causes cell death by intercalating DNA and inhibiting replication. This product displays no obvious toxicity without a primary antibody and can be a quite efficient and economical alternative to pre-screening human monoclonal antibodies as ADC candidates.
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Specifications
- Antibody Overview
- anti-human IgG Fc specific polyclonal IgG antibody
- Antibody Isotype
- IgG
- Linker
- CL
- Linker Class/Description
- Class: Cleavable linkers
Description: Cleavable linkers rely on processes inside the cell to liberate the toxin, such as reduction in the cytoplasm, exposure to acidic conditions in the lysosome, or cleavage by specific proteases within the cell.
- Drug
- PNU-159682
- Drug Class/Description
- Class: Nemorubicin
Description: Nemorubicin is a 3'-deamino-3'[2-(S)-methoxy-4-morpholinyl] derivative of doxorubicin. Doxorubicin is the generic name for the trade name drug, Adriamycin®, as well as, Rubex®, which is a type of anti-cancer chemotherapy drug called an anthracycline. Doxorubicin works by blocking an enzyme called TopoisomeraseⅡthat cancer cells need to divide and grow.
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-548 | Recombinant Anti-IgG Fc Antibody | ELISA, WB, Dot, FuncS | IgG |
| MHH-548 | Recombinant Human Anti-IgG Fc Antibody | IF, Neut, FuncS | IgG |
| PABZ-080 | Human Anti-IgG Fc Recombinant Antibody (PABZ-080) | WB, IF, FuncS | Human IgG |
| HPAB-S0071-YC | Human Anti-IgG Fc Recombinant Antibody (clone RF-AN) | ELISA | Human IgM |
| FAMAB-0023JF | Human Anti-IgG Fc Recombinant Antibody (clone A4) | ELISA, FuncS | Human IgM |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-548-F(E) | Recombinant Anti-IgG Fc Antibody Fab Fragment | ELISA, IP, FuncS | Fab |
| MHH-548-F(E) | Recombinant Human Anti-IgG Fc Antibody Fab Fragment | WB, Dot, FuncS | Fab |
| PFBZ-080 | Human Anti-IgG Fc Recombinant Antibody; Fab Fragment (PFBZ-080) | WB, IF, FuncS | Human Fab |
| HPAB-S0071-YC-F(E) | Human Anti-IgG Fc Recombinant Antibody (clone RF-AN); Fab Fragment | ELISA | Human Fab |
| FAMAB-0023JF-F(E) | Human Anti-IgG Fc Recombinant Antibody (clone A4); Fab Fragment | WB, FC, ELISA, FuncS | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-548-S(P) | Recombinant Anti-IgG Fc Antibody scFv Fragment | WB, IF, FuncS | scFv |
| MHH-548-S(P) | Recombinant Human Anti-IgG Fc Antibody scFv Fragment | WB, ELISA, IHC, FuncS | scFv |
| HPAB-S0071-YC-S(P) | Human Anti-IgG Fc Recombinant Antibody (clone RF-AN); scFv Fragment | ELISA | Human scFv |
| FAMAB-0023JF-S(P) | Human Anti-IgG Fc Recombinant Antibody (clone A4); scFv Fragment | WB, FC, ELISA, FuncS | Human scFv |
| FAMAB-0024JF-S(P) | Human Anti-IgG Fc Recombinant Antibody (clone NA6); scFv Fragment | WB, FC, ELISA, FuncS | Human scFv |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0356MC | FITC anti-Human IgG Fc Antibody | FC |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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