anti-HIgG(Fc)Fab-C-DMDM ADC
CAT#: ADC-1013-SHFz
This ADC product is composed of a Fab fragment of an anti-human IgG Fc specific polyclonal antibody conjugated via a cleavable linker to DMDM (anti-human IgG(Fc)Fab-CL-DMDM). The antibody portion is a Fab fragment of a secondary antibody and the drug portion, duocarmycin DM (DMDM), is a cytotoxic small molecule which causes cell death by binding to the minor groove of DNA and alkylating the adenine. This product displays no obvious toxicity without a primary antibody and can be a quite efficient and economical alternative to pre-screening human monoclonal antibodies as ADC candidates.
Specifications
- Antibody Overview
- Fab fragment of anti-human IgG Fc specific polyclonal antibody
- Antibody Isotype
- IgG
- Linker
- CL
- Linker Class/Description
- Class: Cleavable linkers
Description: Cleavable linkers rely on processes inside the cell to liberate the toxin, such as reduction in the cytoplasm, exposure to acidic conditions in the lysosome, or cleavage by specific proteases within the cell.
- Drug
- DMDM (duocarmycin DM)
- Drug Class/Description
- Class: Duocarmycins
Description: Duocarmycins belong to the minor-groove-binding DNA-alkylating agents (DNA MGBA). The natural duocarmycins are isolated from the culture broth of Streptmyces sp and a series of derivatives has also been synthesized
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Economical Screening Tool
This secondary ADC has been a fantastic alternative to producing custom conjugates. We used it to screen our panel of human antibodies. The anti-human IgG Fc Fab fragment bound our primary antibodies well, and the DMDM payload provided a clear cytotoxic readout.
Effective DNA Minor Groove Binder
The Duocarmycin DM payload is a potent DNA alkylating agent. We observed cell death consistent with DNA minor groove binding. This product allowed us to quickly assess the internalization potential of our antibody candidates without extensive synthesis.
Q&As
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What is the main application of this secondary ADC product?
A: This product is designed as an efficient and economical alternative to pre-screening human monoclonal antibodies. It allows researchers to test the efficacy of their primary anti-human IgG antibodies as ADC candidates without needing to perform individual conjugations.
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How does the DMDM payload cause cell death?
A: The drug portion, duocarmycin DM (DMDM), is a cytotoxic small molecule. It causes cell death by binding to the minor groove of DNA and alkylating the adenine base, which disrupts DNA function and integrity.
View the frequently asked questions answered by Creative Biolabs Support.
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