anti-HIgG(Fc)Fab-C-MMAF ADC (CAT#: ADC-1010-SHFz)
This ADC product is composed of a Fab fragment of an anti-human IgG Fc specific polyclonal antibody conjugated via a cleavable linker to MMAF (anti-human IgG(Fc)Fab-CL-MMAF). The antibody portion is a Fab fragment of a secondary antibody and the drug portion, MMAF, is a cytotoxic small molecule which inhibits cell division by depolymerizing microtubules. This product displays no obvious toxicity without a primary antibody and can be a quite efficient and economical alternative to pre-screening human monoclonal antibodies as ADC candidates.
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Specifications
- Antibody Overview
- Fab fragment of anti-human IgG Fc specific polyclonal antibody
- Antibody Isotype
- IgG
- Linker
- CL
- Linker Class/Description
- Class: Cleavable linkers
Description: Cleavable linkers rely on processes inside the cell to liberate the toxin, such as reduction in the cytoplasm, exposure to acidic conditions in the lysosome, or cleavage by specific proteases within the cell.
- Drug
- MMAF (Monomethyl auristatin F)
- Drug Class/Description
- Class: Auristatin
Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
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