anti-HIgG(Fc)Fab-C-PNU ADC (CAT#: ADC-1014-SHFz)
This ADC product is composed of a Fab fragment of an anti-human IgG Fc specific polyclonal antibody conjugated via a cleavable linker to PNU-159682 (anti-human IgG(Fc)Fab-CL-PNU). The antibody portion is a Fab fragment of a secondary antibody and the drug portion, PNU-159682, is a derivative of nemorubicin which causes cell death by intercalating DNA and inhibiting replication. This product displays no obvious toxicity without a primary antibody and can be a quite efficient and economical alternative to pre-screening human monoclonal antibodies as ADC candidates.
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Specifications
- Antibody Overview
- Fab fragment of anti-human IgG Fc specific polyclonal antibody
- Antibody Isotype
- IgG
- Linker
- CL
- Linker Class/Description
- Class: Cleavable linkers
Description: Cleavable linkers rely on processes inside the cell to liberate the toxin, such as reduction in the cytoplasm, exposure to acidic conditions in the lysosome, or cleavage by specific proteases within the cell.
- Drug
- PNU-159682
- Drug Class/Description
- Class: Nemorubicin
Description: Nemorubicin is a 3'-deamino-3'[2-(S)-methoxy-4-morpholinyl] derivative of doxorubicin. Doxorubicin is the generic name for the trade name drug, Adriamycin®, as well as, Rubex®, which is a type of anti-cancer chemotherapy drug called an anthracycline. Doxorubicin works by blocking an enzyme called TopoisomeraseⅡthat cancer cells need to divide and grow.
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For Research Use Only. Not For Clinical Use.
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