anti-HIgG(Fc)Fab-N-AAMT ADC (CAT#: ADC-1016-SHFz)

• Antibody Overview
• Fab fragment of anti-human IgG Fc specific polyclonal antibody

• Antibody Isotype
• IgG

• Linker
• NC

• Linker Class/Description
• Class: Noncleavable linkers
  Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.

• Drug
• Alfa-amanitin

• Drug Class/Description
• Class: Amatoxins
  Description: Amatoxins are a family of highly toxic cyclopeptides with the ability of inhibiting transcription, which are produced by mushrooms, particularly of the genusAmanita. The nine naturally occurring amatoxins known so far share the same skeletal structure, a ring of eight L-configurated amino acids, bridged between a tryptophan and a cysteine residue by a sulfoxide moiety.

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