anti-HIgG(Fc)Fab-N-DM1 ADC
CAT#: ADC-1015-SHFz
This ADC product is composed of a Fab fragment of an anti-human IgG Fc specific polyclonal antibody conjugated via a non-cleavable linker to DM1 (anti-human IgG(Fc)Fab-NC-DM1). The antibody portion is a Fab fragment of a secondary antibody and the drug portion, DM1, is a cytotoxic small molecule which inhibits cell division by depolymerizing microtubules. This product displays no obvious toxicity without a primary antibody and can be a quite efficient and economical alternative to pre-screening human monoclonal antibodies as ADC candidates.
Specifications
- Antibody Overview
- Fab fragment of anti-human IgG Fc specific polyclonal antibody
- Antibody Isotype
- IgG
- Linker
- NC
- Linker Class/Description
- Class: Noncleavable linkers
Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
- Drug
- DM1
- Drug Class/Description
- Class: Maytansinoid
Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansamacrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells
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