Human Anti-CXCL13 (clone E10) scFv-Fc Chimera
CAT#: VS-0125-FY62
Anti-CXCL13 scFv-Fc targets CXCL13, a chemokine that plays an important role in lymphoid tissue and inflammatory responses. CXCL13 is primarily associated with the recruitment and activation of B cells, and therefore may play a significant role in immune responses and certain diseases, such as autoimmune diseases and tumor microenvironments. E10 is a leading scFv variant or clone obtained from the screening process, which has achieved significant improvements in affinity and stability for CXCL13 through mutations in the VL-CDR3 region.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human bone marrow
Immunohistochemical staining of human bone marrow shows cytoplasmic positivity in hematopoietic cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52613/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52613/126780_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52613/126780_A_9_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52613/126780_A_7_5.jpg
Normal Tissue
Figure 5 Testis
Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52613/126780_A_4_6.jpg
Normal Tissue
Figure 6 Bone marrow
Hematopoietic cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/52613/126780_B_5_4.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (U-266/70)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000156234-CXCL13
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- E10
- Applications
- Immunoassay
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- C-X-C Motif Chemokine Ligand 13; Small Inducible Cytokine B Subfamily (Cys-X-Cys Motif), Member 13 (B-Cell Chemoattractant); B Cell-Attracting Chemokine 1; B Lymphocyte Chemoattractant; Small-Inducible Cytokine B13; B-Cell Chemoattractant; CXC Chemokine BLC; SCYB13; ANGIE; BCA-1; BCA1
- Gene ID
- 10563
- UniProt ID
- O43927
- Sequence Similarities
- Belongs to the intercrine alpha (chemokine CxC) family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Modification sites at PhosphoSitePlus
Modification sites at neXtProt
- Protein Refseq
- NP_001358487.1; NP_006410.1
- Function
- Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils.
Does not induce calcium release in B-lymphocytes.
Binds to BLR1/CXCR5.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "Clone E10"
- CAT
- Product Name
See other products for "CXCL13"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2335z | Mouse Anti-CXCL13 Recombinant Antibody (clone 24G7) | WB, ELISA, FC, IHC, Neut | Mouse IgG1 |
| MOB-0904MZ | Recombinant Mouse Anti-Human CXCL13 Antibody (clone NN0323-23B3) | Neut | Mouse antibody |
| HPAB-0060-CN | Human Anti-CXCL13 Recombinant Antibody (clone Ab 1) | FC, ELISA, WB, IF | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-104MZ | Anti-Human CXCL13 Recombinant Antibody (MAb 1476) | ELISA | Chimeric antibody (mouse/human) |
| TAB-104MZ-S(P) | Anti-Human CXCL13 Recombinant Antibody scFv Fragment (MAb 1476) | ELISA | Chimeric antibody (mouse/human) |
| TAB-104MZ-F(E) | Anti-Human CXCL13 Recombinant Antibody Fab Fragment (MAb 1476) | ELISA | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-105MZ | Anti-Human CXCL13 Recombinant Antibody (MAb 5080) | ELISA | Humanized antibody |
| TAB-106MZ | Anti-Human CXCL13 Recombinant Antibody (MAb 5261) | ELISA | Humanized antibody |
| TAB-107MZ | Anti-Human CXCL13 Recombinant Antibody (MAb 5378) | ELISA | Humanized antibody |
| TAB-105MZ-S(P) | Anti-Human CXCL13 Recombinant Antibody scFv Fragment (MAb 5080) | ELISA | Humanized antibody |
| TAB-106MZ-S(P) | Anti-Human CXCL13 Recombinant Antibody scFv Fragment (MAb 5261) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-108MZ | Anti-Human CXCL13 Recombinant Antibody | cAMP assay | Human antibody |
| TAB-110MZ | Anti-Human CXCL13 Recombinant Antibody (3B4) | ELISA | Human antibody |
| PABX-041 | Human Anti-CXCL13 Recombinant Antibody (PABX-041) | Neut, FuncS, PK, ELISA | Human IgG |
| PABX-041-S (P) | Human Anti-CXCL13 Recombinant Antibody; scFv Fragment (PABX-041-S (P)) | Neut, FuncS | Human scFv |
| PABX-041-F (E) | Human Anti-CXCL13 Recombinant Antibody; Fab Fragment (PABX-041-F (E)) | Neut, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0149MZ | Chicken Anti-CXCL13 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-613CQ | Mouse Anti-CXCL13 Recombinant Antibody (clone 12A2) | Neut, WB | Mouse IgG1 |
| NEUT-614CQ | Mouse Anti-CXCL13 Recombinant Antibody (clone MM0212-12A2) | Neut, WB | Mouse IgG1 |
| NEUT-615CQ | Mouse Anti-CXCL13 Recombinant Antibody (clone CBL037) | Neut, WB | Mouse IgG1 |
| NEUT-616CQ | Mouse Anti-CXCL13 Recombinant Antibody (clone CBL799) | WB, CyTOF®, ELISA, ICFC, Neut | Mouse IgG1 |
| NEUT-617CQ | Rat Anti-Cxcl13 Recombinant Antibody (clone 19N1) | Neut, WB | Rat IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0060-CN-S(P) | Human Anti-CXCL13 Recombinant Antibody (clone Ab 1); scFv Fragment | FC, ELISA, WB, IF | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0060-CN-F(E) | Human Anti-CXCL13 Recombinant Antibody (clone Ab 1); Fab Fragment | FC, ELISA, WB, IF | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY12 | Human Anti-CXCL13 (clone W253B4) scFv-Fc Chimera | ELISA, Neut | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1815 | Anti-CXCL13 Immunohistochemistry Kit | IHC | |
| VS-0525-XY1816 | Anti-Mouse CXCL13 Immunohistochemistry Kit | IHC |
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