Human Anti-CXCL13 (clone E10) scFv-Fc Chimera (CAT#: VS-0125-FY62)
Anti-CXCL13 scFv-Fc targets CXCL13, a chemokine that plays an important role in lymphoid tissue and inflammatory responses. CXCL13 is primarily associated with the recruitment and activation of B cells, and therefore may play a significant role in immune responses and certain diseases, such as autoimmune diseases and tumor microenvironments. E10 is a leading scFv variant or clone obtained from the screening process, which has achieved significant improvements in affinity and stability for CXCL13 through mutations in the VL-CDR3 region.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human bone marrow
(Immunohistochemical staining of human bone marrow shows cytoplasmic positivity in hematopoietic cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52613/ihc_selected.jpg
(Immunohistochemical staining of human bone marrow shows cytoplasmic positivity in hematopoietic cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52613/ihc_selected.jpg
Figure 2 Cerebral cortex
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52613/126780_B_8_5.jpg
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52613/126780_B_8_5.jpg
Figure 3 Colon
(Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52613/126780_A_9_3.jpg
(Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52613/126780_A_9_3.jpg
Figure 4 Kidney
(Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52613/126780_A_7_5.jpg
(Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52613/126780_A_7_5.jpg
Figure 5 Testis
(Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52613/126780_A_4_6.jpg
(Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52613/126780_A_4_6.jpg
Figure 6 Bone marrow
(Hematopoietic cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52613/126780_B_5_4.jpg
(Hematopoietic cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/52613/126780_B_5_4.jpg
Figure 7 RNA cell line category: Cell line enhanced (U-266/70)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000156234-CXCL13
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000156234-CXCL13
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- E10
- Applications
- Immunoassay
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- C-X-C Motif Chemokine Ligand 13; Small Inducible Cytokine B Subfamily (Cys-X-Cys Motif), Member 13 (B-Cell Chemoattractant); B Cell-Attracting Chemokine 1; B Lymphocyte Chemoattractant; Small-Inducible Cytokine B13; B-Cell Chemoattractant; CXC Chemokine BLC; SCYB13; ANGIE; BCA-1; BCA1
- Gene ID
- 10563
- UniProt ID
- O43927
- Sequence Similarities
- Belongs to the intercrine alpha (chemokine CxC) family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Modification sites at PhosphoSitePlus
Modification sites at neXtProt
- Protein Refseq
- NP_001358487.1; NP_006410.1
- Function
- Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils.
Does not induce calcium release in B-lymphocytes.
Binds to BLR1/CXCR5.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2335z | Mouse Anti-CXCL13 Recombinant Antibody (clone 24G7) | WB, ELISA, FC, IHC, Neut | Mouse IgG1 |
| MOB-0904MZ | Recombinant Mouse Anti-Human CXCL13 Antibody (clone NN0323-23B3) | Neut | Mouse antibody |
| HPAB-0060-CN | Human Anti-CXCL13 Recombinant Antibody (clone Ab 1) | FC, ELISA, WB, IF | Human IgG1 |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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